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Gene 1 Gene 2 Interaction Type Sentence Value Judge me
Ras Rho interact1 A novel Rho GTPase-activating-protein interacts with Gem , a member of the Ras superfamily of GTPases . 82 good bad
Ras Raf bind1 At either location Raf kinase activity was inhibited by lipid binding in the absence or presence of Ras . 79 good bad
Ras Ras complex1 Here , the methods of continuum electrostatics are used to investigate the contribution of electrostatic interactions to the binding of four protein-protein complexes ; barnase-barstar , human growth 51 good bad
Ras p42 interact3 The signaling pathways that are rapidly elicited by the interaction of ouabain with Na + K + -ATPase , and are independent of changes in intracellular Na + and K + concentrations , include activation 48 good bad
ras TESK1 interact1 Human sprouty 4 , a new ras antagonist on 5q31 , interacts with the dual specificity kinase TESK1 . 47 good bad
Ras ceramide interact1 The KSR1 C1 domain does not bind with high affinity or respond biologically to phorbol esters or ceramide , and it does not interact directly with Ras , indicating that the putative ligand ( s ) for t 43 good bad
Ras CREB bind1 Once activated , the CaMK , Ras ERK , and SAPK pathways lead to the phosphorylation and activation of transcription factors in the nucleus such as the cyclic AMP response element binding protein ( CR 39 good bad
Ras heregulin bind3 We have found using differential display of mRNA that the growth factor heregulin beta 1 ( HRG ) , a combinatorial ligand for human epidermal growth factor receptors ( HERs ) , induced expression of G 29 good bad
RAS RIN1 bind3 At concentrations close to their equilibrium dissociation constant values , RIN1 and RAF1 compete directly for RAS binding . 28 good bad
Ras Rb bind1 In addition , we present evidence that cooperation between the N-terminal fragment and Ras depends upon an intact T-antigen J domain and the ability of the T antigen to bind and inactivate the growth- 22 good bad
RAS ACE bind3 We studied the relation between renin-angiotensin system ( RAS ) related gene polymorphisms , such as angiotensin converting enzyme ( ACE ) insertion deletion ( I D ) , angiotensinogen ( AGT ) M253T 17 good bad
Ras Notch interact3 Reciprocal regulatory interactions between the Notch and Ras signaling pathways in the Drosophila embryonic mesoderm . 17 good bad
RAS HGF bind1 Moreover , HGF binding to syndecan-1 promotes activation of the phosphatidylinositol 3-kinase protein kinase B and RAS mitogen-activated protein kinase pathways , signaling routes that have been imp 12 good bad
Ras Src bind3 , Ras and Src ) , or inactivation of several important actin-binding proteins that have tumor suppressive functions ( e . 10 good bad
ras GTP bind1 Finally , the levels of three small guanosine-5 ' -triphosphate ( GTP ) binding proteins were screened upon differentiation showing rab3A to be increased while rhoA and H-ras were decreased . 9 good bad
ras DCC associate2 To test this hypothesis , we investigated the age-associated changes in mutation of adenomatous polyposis coli ( APC ) , deleted in colorectal cancer ( DCC ) , p53 , and K-ras genes in the gastric muc 8 good bad
ras K-ras associate1 CONCLUSIONS : These findings suggest that K-ras may be associated with PTHrP-induced hypercalcaemia and that PTHrP levels may reflect the aggressiveness of tumour cells through the K-ras oncogene in R 8 good bad
ras NF1 associate1 There is increasing evidence that loss of NF1 expression in neoplastic Schwann cells is associated with elevated levels of activated RAS , supporting the notion that the NF1 gene product , neurofibrom 8 good bad
Ras sgk bind3 Several aldosterone-sensitive genes , including serum and glucocorticoid-inducible kinase ( sgk ) and small , monomeric Kirsten Ras GTP-binding protein ( Ki-ras ) have recently been identified . 8 good bad
Ras CR2 bind1 Disruption of 14-3-3 binding at CR2 did not recover binding of Raf-1 to ( V12 , G37 ) Ras but allowed more efficient recruitment of Raf-1 to the plasma membrane and stimulated its phosphorylation on S 7 good bad
Ras gap associate2 [ Effect of d-limonene , salvia miltiorrhiza and turmeric derivatives on membrane association of Ras gene product and gap junction intercellular communication ] 7 good bad
ras p15 bind1 Among the lines , three lines had mutations in codon 12 in K- ras , two lines harbored p53 mutations within the DNA-binding domain ; two lines had homozygous deletions in both p16 and p15 genes ; and 7 good bad
Ras Rac associate3 Ras and Rac are membrane-associated GTPases that function as molecular switches activating intracellular mitogen-activated protein kinase ( MAPK ) cascades and other effector pathways in response to e 7 good bad
Ras Ras complex1 The discovery of a new downstream target for the Ras GTPases - a Nore1-Mst1 protein complex - reveals a mechanism by which Ras can promote apoptosis , and suggests that the influence of Ras on cell su 7 good bad
Ras Rho associate2 However , no protein acting like Rho and Rab dissociation inhibitor ( GDI ) that regulate the membrane association of Rho and Rab GTPases has been described for Ras and closely related proteins . 7 good bad
Ras AP-1 bind3 Since many examples of apoptosis have been reported to involve AP-1 and or the AP-1-activating enzyme Jun kinase ( JNK ) , downstream effectors of Ras or Ras-like small GTP-binding proteins , we eval 6 good bad
ras APC associate2 No association was found between MSI-L ( or the level of MSI ) and any clinicopathological or molecular variable , including K-ras mutation and loss of heterozygosity at APC . 6 good bad
Ras EGF associate1 Elevated expression of epidermal growth factor ( EGF ) receptor in many cancers is associated with progression of superficial to invasive forms of the disease and is sometimes found in tumors that als 6 good bad
Ras Grb2 bind2 This resulted in increased binding of another adaptor protein Grb2 to the Src-EGFR complex and the subsequent activation of Ras and MAPKs . 6 good bad
Ras MAPK bind1 The Ras family of GTP-binding proteins are key transducers of extracellular signals , particularly through the mitogen-activated protein kinase ( MAPK ) pathway . 6 good bad
ras p16 complex2 METHODS : Expression of HCV antigens ( CP10 , NS3 and NS5 ) and several cancer-associated gene products ( ras p21 , c-myc , c-erbB-2 , mutated p53 and p16 protein ) in the tissues of hepatocellular ca 6 good bad
Ras RACK1 associate3 Whereas most of RACK1 resides in the cytoskeletal compartment of the cytoplasm , transformation of fibroblasts and epithelial cells by v-Src , oncogenic IR or oncogenic IGF-IR , but not by Ros or Ras 6 good bad
Ras Raf bind1 Ras proteins transduce extracellular signals to intracellular signaling pathways by binding to and promoting the activation of at least three classes of downstream signaling molecules : Raf kinases , 6 good bad
Ras Raf bind1 The analysis of the missense mutations indicates that Ras binding , 14-3-3-binding , and protein kinase activity are necessary for full Raf function and suggests that a 14-3-3 protein positively regul 6 good bad
Ras GTP associate1 Ras association with Raf was GTP dependent as previously demonstrated for C-Raf-RBD fragments . 5 good bad
RAS NF1 associate1 BACKGROUND : The effectiveness of percutaneous transluminal angioplasty ( PTA ) in renal artery stenosis ( RAS ) associated with neurofibromatosis type 1 ( NF1 ) has not been established . 5 good bad
Ras p65 associate1 The resultant chimeric p65 ( Tpr-Met ) protein is constitutively phosphorylated on tyrosine residues in vivo and associates with a number of SH2-containing signaling molecules including the p85 subuni 5 good bad
ras TESK1 interact1 Human sprouty 4 , a new ras antagonist on 5q31 , interacts with the dual specificity kinase TESK1 . 5 good bad
ras TNM associate2 No statistically significant association between results of K-ras mutations and TNM stage of disease was found . 5 good bad
Ras calcineurin interact1 Wing and eye phenotypes of ectopic activated calcineurin and genetic interactions with components of signaling pathways suggested a role for calcineurin in repressing Egf receptor Ras signal transduc 4 good bad
Ras EF bind1 RasGRP4 contains the same protein domain structure as other members of the RasGRP family , including a Ras exchange motif , a CDC25 homology domain , a C1 diacyglycerol binding domain , and putative 4 good bad
Ras ERK1 interact3 The inhibition of Grb2-SOS interaction with an SH3 binding sequence peptide , Ras with a farnesyl transferase inhibitor , and Raf-1 with forskolin did not affect the stretch-induced ERK1 2 phosphoryl 4 good bad
Ras GTP bind1 The small guanosine triphosphate ( GTP ) binding protein Ras is involved in many cellular signal transduction processes leading to cell growth , differentiation and apoptosis . 4 good bad
Ras Pak1 bind1 Pak1 ( L83 , L86 , R299 ) , a mutant that fails to bind either Rac or Cdc42 , also inhibited Ras transformation . 4 good bad
Ras Raf interact2 We used Ras and Raf proteins in the yeast two-hybrid system to search for natural or synthesized substances capable of modulating Ras Raf interaction by specifically binding to one of the interacting 4 good bad
Ras Rho bind1 The Rho family of proteins , incluing the Rho , Rac and Cdc42 subfamilies , are related to the small GTP binding protein Ras and regulated diverse biological processes including gene transcription , c 4 good bad
Ras Rho bind3 Studies with Ras and Rho have elucidated the mechanism of GAP action by showing that their catalytic machinery is both stabilized by GAP binding and complemented by the insertion of a so-called ' argi 4 good bad
Ras Rho complex1 Dystrophin-glycoprotein complex and Ras and Rho GTPase signaling are altered in muscle atrophy . 4 good bad
ras map complex1 coli nucleotide excision enzyme complex , UvrABC nucleases in combination with ligation-mediated polymerase chain reaction , we developed a method to map DNA damage in the p53 and ras genes . 3 good bad
Ras Raf associate1 Cytosolic GTP-bound Ras mutants could be used to inhibit particular Ras effectors by introducing additional mutations ( T35S , E37G or Y40C ) that permit them to associate selectively with and inhibit 3 good bad
ras APC associate2 The characteristics and very existence of low-level instability ( MSI-L ) are unclear , although some studies have found associations between MSI-L and molecular characteristics , notably more frequen 1 good bad
RAS B8 associate2 To characterize genetic events associated with B8 mouse astrocytoma formation , we employed comparative gene expression profiling of wild-type cultured mouse astrocytes , non-neoplastic B8 astrocytes 1 good bad
Ras TC21 interact1 In this study , we determined that TC21 interacts strongly with some ( RalGDS , RGL , RGL2 Rlf , AF6 , and the phosphatidylinositol 3-kinase ( PI3K ) catalytic subunit p110delta ) , and weakly with o 1 good bad
RAS RAF1 bind1 We demonstrate that the RAS effector protein RIN1 binds to activated RAS with an affinity ( K ( d ) , 22 nM ) similar to that observed for RAF1 . 0 good bad
RAS HLA interact3 Cox proportional hazards estimation showed no interactions between the observed effect of CYP11B2 genotype on renal function over time and the number of HLA class I and II matches , other RAS genotype -1 good bad
Ras actin interact1 Because Ras homologous protein ( Rho ) induces actin microfilament polymerization , interacts with microtubules , and is believed to be activated by growth factors , we set forth to study the regulato -11 good bad
Ras Src associate3 CRCs accompanied by ulcerative colitis , chronic inflammation in the colon , often have elevated Src activity , and ulcerative colitis-related CRCs are more likely to become invasive , whereas Ras act -15 good bad
Ras MST1 associate1 Endogenous NORE and MST1 occur in a constitutive complex in vivo that associates with endogenous Ras after serum stimulation . -16 good bad
Ras Msn2 complex1 Together , our results suggest that the Ccr4-Not complex may function as an effector of the Ras cAMP pathway that contributes to repress basal , stress- and starvation-induced transcription by Msn2 -18 good bad
ras myc associate2 In Western countries , most cases of PT-LPD are B-cell-derived and Epstein-Barr virus-associated , in which alterations of c-myc , p53 , and N-ras genes might play a role in disease progression . -30 good bad
ras D1 associate2 There were no significant associations between cyclin D1 overexpression and k-ras mutation or response to 5FU . -33 good bad
RAS SHS interact3 However , the potential interaction between SHS and the RAS is unknown . -36 good bad
ras c-myc associate3 Cotransfection of rat embryo fibroblasts with c-myc and activated H-ras oncogenes is one experimental model of the multistep oncogenesis associated with p53 mutations and aneuploidy . -43 good bad
Ras EBP bind3 The current study demonstrates that activated Ras enhances the ability of C EBPalpha to transactivate the G-CSF receptor promoter and a minimal promoter containing only C EBP DNA binding sites . -47 good bad
Ras GTP bind1 In contrast , the GTP analogue 3 , 4-diaminobenzophenone ( DABP ) -phosphoramidate-GTP , a substrate for GTP-binding proteins , enables switching to the inactive GDP form in both wild-type and oncogen -72 good bad
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Text2Knowledge ... Yong Huang 2002