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Introduction
Efficient RNA sequence manipulations (like multiple alignments) need to be constrained by rules of RNA structure folding. The structural knowledge has increased dramatically in the last years with the accumulation of several large RNA structures like those of the bacterial ribosome subunits. However, no tool in the RNA community provides an easy way to link and integrate progress made at the sequence level using the available three-dimensional information.

S2S proposes a framework in which a user can easily display, manipulate, and interconnect heterogeneous RNA data like multiple sequence alignments, secondary and tertiary structures. It has been implemented with the Java language and has been developed and tested under UNIX systems like Linux and MacOSX.

S2S 1.0 has been published in 2005 in the Bioinformatics journal (Jossinet F. and Westhof E., 2005). This website describes the 2.0 version of S2S.

If you use this program please cite:
Jossinet, F, and E Westhof. 2005. “Sequence to Structure (S2S): Display, Manipulate and Interconnect RNA Data From Sequence to Structure.”. Bioinformatics 21:3320-1.
On this website, you will find: For any questions or remarks, feel free to contact us.
Links
Contacts
The S2S project is managed by Dr. Fabrice Jossinet. It is developed in the laboratory of Pr. Eric Westhof at the "Institut de Biologie Moleculaire et Cellulaire" of Strasbourg, France (Team "Architecture et Réactivité de l'ARN", UPR 9002 of CNRS, Université de Strasbourg).

For any questions or remarks, please contact f[dot]jossinet[at]ibmc[dot]u-strasbg[dot]fr (if you're not a robot, you will know what to do with this email!!)