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Opportunity: Bioinformatics Research Scientist @ St. Jude Children's Research Hospital -- Memphis, TN (US)
Submitted by Kirt Woodruff; posted on Friday, March 19, 2021
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BACKGROUND
A bioinformatics research scientist position is available in the field of pharmacogenomics in the Savic laboratory. The primary research focus of the Savic laboratory involves studying the gene regulatory architecture of pediatric leukemia and genomic responses to antileukemic agents in order to define how the noncoding portion of the human genome impacts chemotherapeutic drug response, chemotherapeutic drug resistance and leukemia relapse. To address these critical questions, the Savic laboratory uses functional genomics (ChIP-seq, ATAC-seq, RNA-seq, Hi-C, etc.) to map cis-regulatory elements and noncoding sequence variants in primary leukemia cells from patients and further applies high-throughput approaches (STARR-seq, MPRA, CRISPR screening, etc.) to functionally characterize their impact on gene regulation and pharmacological phenotypes using both in vitro and ex vivo models. The long-term goal of the Savic laboratory is to gain a better understanding of the genetic underpinnings of chemotherapeutic drug resistance and relapse in pediatric leukemia.
RESPONSIBILITIES
The successful candidate will be responsible for analyzing and integrating orthogonal genomic datasets in order to infer the pharmacogenomic impact of cis-regulatory elements and noncoding sequence variants. To meet these tasks, the candidate will be responsible for implementing, building and managing analytical pipelines for collaborative projects within the laboratory and beyond the laboratory.
REQUIREMENTS
- Ph.D. in Molecular Biology, Biochemistry, Computer Science, Bioinformatics or related field required
- Ph.D which must include research related to bioinformatics (such as analysis of sequence data, SNPs, methylation, or biological pathways; development of algorithms, statistical methods, or scientific software); OR If Ph.D with no bioinformatics research, then two (2) years of pre-or postdoctoral experience in Computational Biology or Bioinformatics research is required
- Experience with programming languages such as Perl, C, Python or Java required
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