BIRC5

 

SYNONYMS baculoviral IAP repeat-containing 5 EPR-1 apoptosis inhibitor 4 (survivin) survivin API4 SVV

Biochemical family Survivin is a member of the inhibitor of apoptosis (IAP) gene family, containing a single baculovirus IAP repeat (BIR) and no RING finger, that is expressed in many human cancers. Jiang X, Wilford C, Duensing S, Munger K, Jones G, Jones D.

Cell cycle Survivin colocalizes with centrosomes in the cytoplasm during interphase, then moves to centromeres during mitosis, and finally localizes to the midbody spindle fibers during telophase. Jiang X, Wilford C, Duensing S, Munger K, Jones G, Jones D.

Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin. O'Connor DS, Grossman D, Plescia J, Li F, Zhang H, Villa A, Tognin S, Marchisio PC, Altieri DC.

Cell location Survivin colocalizes with centrosomes in the cytoplasm during interphase, then moves to centromeres during mitosis, and finally localizes to the midbody spindle fibers during telophase. Jiang X, Wilford C, Duensing S, Munger K, Jones G, Jones D.

Clinical Survivin as a radioresistance factor in pancreatic cancer. Asanuma K, Moriai R, Yajima T, Yagihashi A, Yamada M, Kobayashi D, Watanabe N.

Survivin as a potential new target forapoptosis-based therapy   in cancer. Ambrosini G, Adida C, Altieri DC.

Development Present during fetal development, survivin is undetectable in terminally differentiated adult tissues. Ambrosini G, Adida C, Altieri DC.

Survivin in several apoptosis-regulated fetal tissues, including the stem cell layer of stratified epithelia, endocrine pancreas, and thymic medulla. Adida C, Crotty PL, McGrath J, Berrebi D, Diebold J, Altieri DC.

Function   Survivin as a radioresistance factor in pancreatic cancer. Asanuma K, Moriai R, Yajima T, Yagihashi A, Yamada M, Kobayashi D, Watanabe N.

Gene type  A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Ambrosini G, Adida C, Altieri DC.

Homologue In mouse embryo, prominent and nearly ubiquitous distribution of survivin was found at embryonic day (E)11.5, whereas at E15 to –21. Adida C, Crotty PL, McGrath J, Berrebi D, Diebold J, Altieri DC.

Isolation and mapping the pig homologs survivin (BIRC5) and effector cell protease receptor 1 (EPR1) genes. Cirera S, Fredholm M.

Oncogenic Activation Survivin becomes prominently expressed in transformed cell lines and in all the most common human cancers of lung, colon, pancreas,prostate and breast, in vivo. Ambrosini G, Adida C, Altieri DC.

Oncogenicity Expression of survivin is correlated with cancer cell apoptosis and is involved in the development of human pancreatic duct cell tumors. Satoh K, Kaneko K, Hirota M, Masamune A, Satoh A, Shimosegawa T.

Regulation Expression of survivin is correlated with cancer cell apoptosis and is involved in the development of human pancreatic duct cell tumors. Satoh K, Kaneko K, Hirota M, Masamune A, Satoh A, Shimosegawa T.