Basic Information
Gene ID 22059 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name Tp53; P53, Trp53
Full Name Cellular tumor antigen p53
Organism Mus musculus [10090]

Cross Reference
UniProt P02340 UniGene Mm.222
PDB 3EXL OMIM NULL
KEGG mmu:22059 UCSC uc007jql.2

Protein Interactions
DIP DIP-369N
IntAct P02340
MINT MINT-120104
STRING 10090.ENSMUSP00000104298

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
NP_035770 Gene3D G3DSA:2.60.40.720 IPR012346 92 290 1.00e-94 p53/RUNT-type transcription factor, DNA-binding domain
NP_035770 Gene3D G3DSA:4.10.170.10 IPR010991 316 355 1.90e-19 p53, tetramerisation domain
NP_035770 PANTHER PTHR11447 IPR002117 1 390 0.00e-00 p53 tumour suppressor family
NP_035770 Pfam PF00870 IPR011615 93 285 3.60e-105 p53, DNA-binding domain
NP_035770 Pfam PF07710 IPR010991 316 355 2.50e-18 p53, tetramerisation domain
NP_035770 Pfam PF08563 IPR013872 9 30 1.30e-07 p53 transactivation domain
NP_035770 PRINTS PR00386 IPR002117 113 139 6.40e-86 p53 tumour suppressor family
NP_035770 PRINTS PR00386 IPR002117 155 176 6.40e-86 p53 tumour suppressor family
NP_035770 PRINTS PR00386 IPR002117 210 231 6.40e-86 p53 tumour suppressor family
NP_035770 PRINTS PR00386 IPR002117 233 255 6.40e-86 p53 tumour suppressor family
NP_035770 PRINTS PR00386 IPR002117 261 283 6.40e-86 p53 tumour suppressor family
NP_035770 PRINTS PR00386 IPR002117 323 347 6.40e-86 p53 tumour suppressor family
NP_035770 ProSitePatterns PS00348 IPR002117 234 246 - p53 tumour suppressor family
NP_035770 SUPERFAMILY SSF47719 IPR010991 316 352 0.00e-00 p53, tetramerisation domain
NP_035770 SUPERFAMILY SSF49417 IPR008967 94 284 0.00e-00 p53-like transcription factor, DNA-binding

Pfam Annotation
Protein Pfam ID E.value Name Description
NP_035770 PF00870 0 P53 P53 DNA-binding domain
NP_035770 PF07710 1.2e-18 P53_tetramer P53 tetramerisation motif
NP_035770 PF08563 1.3e-07 P53_TAD P53 transactivation motif

Gene Ontology Annotation
Protein Entry Name Space Description
NP_035770 GO:0000733 biological_process DNA strand renaturation
NP_035770 GO:0006289 biological_process nucleotide-excision repair
NP_035770 GO:0006351 biological_process transcription, DNA-templated
NP_035770 GO:0006355 biological_process regulation of transcription, DNA-templated
NP_035770 GO:0006915 biological_process apoptotic process
NP_035770 GO:0007049 biological_process cell cycle
NP_035770 GO:0007275 biological_process multicellular organismal development
NP_035770 GO:0007569 biological_process cell aging
NP_035770 GO:0012501 biological_process programmed cell death
NP_035770 GO:0030308 biological_process negative regulation of cell growth
NP_035770 GO:0051262 biological_process protein tetramerization
NP_035770 GO:0090200 biological_process positive regulation of release of cytochrome c from mitochondria
NP_035770 GO:0097252 biological_process oligodendrocyte apoptotic process
NP_035770 GO:0005634 cellular_component nucleus
NP_035770 GO:0005730 cellular_component nucleolus
NP_035770 GO:0005737 cellular_component cytoplasm
NP_035770 GO:0005739 cellular_component mitochondrion
NP_035770 GO:0005759 cellular_component mitochondrial matrix
NP_035770 GO:0005783 cellular_component endoplasmic reticulum
NP_035770 GO:0003677 molecular_function DNA binding
NP_035770 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
NP_035770 GO:0005507 molecular_function copper ion binding
NP_035770 GO:0005524 molecular_function ATP binding
NP_035770 GO:0044212 molecular_function transcription regulatory region DNA binding
NP_035770 GO:0046872 molecular_function metal ion binding