Basic Information
Gene ID 25735 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name Hnf4a; Hnf-4, Hnf4, Nr2a1, Tcf14
Full Name Hepatocyte nuclear factor 4-alpha
Organism Rattus norvegicus [10116]

Cross Reference
UniProt P22449 UniGene Rn.12238
PDB 1M7W OMIM NULL
KEGG rno:25735 UCSC NULL

Protein Interactions
DIP NULL
IntAct P22449
MINT NULL
STRING NULL

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSRNOP00000011978 Gene3D G3DSA:1.10.565.10 IPR008946 145 377 1.70e-74 Nuclear hormone receptor, ligand-binding
ENSRNOP00000011978 Gene3D G3DSA:3.30.50.10 IPR013088 57 139 4.20e-32 Zinc finger, NHR/GATA-type
ENSRNOP00000011978 Pfam PF00104 IPR000536 177 361 6.90e-39 Nuclear hormone receptor, ligand-binding, core
ENSRNOP00000011978 Pfam PF00105 IPR001628 59 127 8.90e-30 Zinc finger, nuclear hormone receptor-type
ENSRNOP00000011978 PRINTS PR00047 IPR001628 109 117 2.90e-18 Zinc finger, nuclear hormone receptor-type
ENSRNOP00000011978 PRINTS PR00047 IPR001628 117 125 2.90e-18 Zinc finger, nuclear hormone receptor-type
ENSRNOP00000011978 PRINTS PR00047 IPR001628 60 76 2.90e-18 Zinc finger, nuclear hormone receptor-type
ENSRNOP00000011978 PRINTS PR00047 IPR001628 76 91 2.90e-18 Zinc finger, nuclear hormone receptor-type
ENSRNOP00000011978 PRINTS PR00398 IPR001723 121 131 3.20e-26 Steroid hormone receptor
ENSRNOP00000011978 PRINTS PR00398 IPR001723 190 211 3.20e-26 Steroid hormone receptor
ENSRNOP00000011978 PRINTS PR00398 IPR001723 211 227 3.20e-26 Steroid hormone receptor
ENSRNOP00000011978 PRINTS PR00398 IPR001723 279 294 3.20e-26 Steroid hormone receptor
ENSRNOP00000011978 PRINTS PR00398 IPR001723 336 353 3.20e-26 Steroid hormone receptor
ENSRNOP00000011978 PRINTS PR01282 IPR003068 183 199 2.50e-07 Transcription factor COUP
ENSRNOP00000011978 PRINTS PR01282 IPR003068 295 307 2.50e-07 Transcription factor COUP
ENSRNOP00000011978 PRINTS PR01282 IPR003068 342 355 2.50e-07 Transcription factor COUP
ENSRNOP00000011978 PRINTS PR01282 IPR003068 362 373 2.50e-07 Transcription factor COUP
ENSRNOP00000011978 PRINTS PR01282 IPR003068 373 386 2.50e-07 Transcription factor COUP
ENSRNOP00000011978 ProSitePatterns PS00031 IPR001628 60 86 - Zinc finger, nuclear hormone receptor-type
ENSRNOP00000011978 ProSiteProfiles PS51030 IPR001628 57 132 0.00e-00 Zinc finger, nuclear hormone receptor-type
ENSRNOP00000011978 SMART SM00399 IPR001628 57 128 2.60e-40 Zinc finger, nuclear hormone receptor-type
ENSRNOP00000011978 SMART SM00430 IPR000536 189 348 3.50e-50 Nuclear hormone receptor, ligand-binding, core
ENSRNOP00000011978 SUPERFAMILY SSF48508 IPR008946 126 374 0.00e-00 Nuclear hormone receptor, ligand-binding

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSRNOP00000011978 PF00104 4.8e-39 Hormone_recep Ligand-binding domain of nuclear hormone receptor
ENSRNOP00000011978 PF00105 5.6e-30 zf-C4 Zinc finger, C4 type (two domains)

Gene Ontology Annotation
Protein Entry Name Space Description
ENSRNOP00000011978 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSRNOP00000011978 GO:0003707 molecular_function steroid hormone receptor activity
ENSRNOP00000011978 GO:0008270 molecular_function zinc ion binding
ENSRNOP00000011978 GO:0043565 molecular_function sequence-specific DNA binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
7029 Acyrthosiphon pisum 100168732 9646 Ailuropoda melanoleuca 100464819
30195 Bombus terrestris 100646806 10029 Cricetulus griseus 100751997
9685 Felis catus 101092841 13735 Pelodiscus sinensis 102450583
6239 Caenorhabditis elegans 172840 9796 Equus caballus 100050783
6087 Hydra magnipapillata 100197146 10224 Saccoglossus kowalevskii 100378202
10141 Cavia porcellus 100713275 132113 Bombus impatiens 100748857
7463 Apis florea 100872065 143995 Megachile rotundata 100879907
34638 Metaseiulus occidentalis 100907131 9597 Pan paniscus 100977071
9555 Papio anubis 100998196 39432 Saimiri boliviensis 101042310
10090 Mus musculus 30942 7227 Drosophila melanogaster 44544
9615 Canis familiaris 485884 9358 Choloepus hoffmanni ENSCHOG00000000938
51511 Ciona savignyi ENSCSAVG00000009430 9365 Erinaceus europaeus ENSEEUG00000009253
9371 Echinops telfairi ENSETEG00000005706 9315 Macropus eugenii ENSMEUG00000001256
59463 Myotis lucifugus ENSMLUG00000000954 9544 Macaca mulatta ENSMMUG00000006464
13616 Monodelphis domestica ENSMODG00000006805 9669 Mustela putorius furo ENSMPUG00000017669
61853 Nomascus leucogenys ENSNLEG00000006596 9978 Ochotona princeps ENSOPRG00000014280
9813 Procavia capensis ENSPCAG00000010776 9598 Pan troglodytes ENSPTRG00000013519
42254 Sorex araneus ENSSARG00000000082 43179 Ictidomys tridecemlineatus ENSSTOG00000020202
37347 Tupaia belangeri ENSTBEG00000010662 99883 Tetraodon nigroviridis ENSTNIG00000012436
9739 Tursiops truncatus ENSTTRG00000013004 7668 Strongylocentrotus purpuratus 574894
7070 Tribolium castaneum 657032 7719 Ciona intestinalis 780712
28377 Anolis carolinensis ENSACAG00000016803 9483 Callithrix jacchus ENSCJAG00000017746
7955 Danio rerio ENSDARG00000021494 10020 Dipodomys ordii ENSDORG00000005971
69293 Gasterosteus aculeatus ENSGACG00000011485 9031 Gallus gallus ENSGALG00000004285
9595 Gorilla gorilla ENSGGOG00000006988 8049 Gadus morhua ENSGMOG00000011421
7897 Latimeria chalumnae ENSLACG00000013810 9785 Loxodonta africana ENSLAFG00000022279
9103 Meleagris gallopavo ENSMGAG00000003970 30608 Microcebus murinus ENSMICG00000008240
9258 Ornithorhynchus anatinus ENSOANG00000006363 9986 Oryctolagus cuniculus ENSOCUG00000006841
30611 Otolemur garnettii ENSOGAG00000029426 8128 Oreochromis niloticus ENSONIG00000016515
8090 Oryzias latipes ENSORLG00000016380 7757 Petromyzon marinus ENSPMAG00000005852
9601 Pongo abelii ENSPPYG00000011031 132908 Pteropus vampyrus ENSPVAG00000007420
9305 Sarcophilus harrisii ENSSHAG00000007693 59729 Taeniopygia guttata ENSTGUG00000005271
31033 Takifugu rubripes ENSTRUG00000009982 9478 Tarsius syrichta ENSTSYG00000007661
30538 Vicugna pacos ENSVPAG00000009648 8364 Xenopus tropicalis ENSXETG00000017845
8083 Xiphophorus maculatus ENSXMAG00000001220