Basic Information | |||
Gene ID | 6772 ; ![]() ![]() | ||
Gene Name | STAT1 | ||
Full Name | Signal transducer and activator of transcription 1-alpha/beta | ||
Organism | Homo sapiens [9606] |
Cross Reference | |||
UniProt | P42224 | UniGene | Hs.743244 |
PDB | 2KA6 | OMIM | 614162 |
KEGG | hsa:6772 | UCSC | uc002usj.2 |
Protein Interactions | |
DIP | DIP-218N |
IntAct | P42224 |
MINT | MINT-120840 |
STRING | 9606.ENSP00000354394 |
Ensembl/RefSeq | Transcript ID | Protein ID | Gene ID |
ENSEMBL | |||
ENSEMBL | |||
ENSEMBL | |||
ENSEMBL | |||
REFSEQ | |||
REFSEQ | |||
REFSEQ |
InterPro Annotation | |||||||
Protein | Program | Term | IPRS | Start | End | Score | Description |
NP_009330 | Gene3D | G3DSA:1.10.238.10 | IPR011992 | 461 | 581 | 5.80e-51 | EF-hand domain pair |
NP_009330 | Gene3D | G3DSA:1.10.532.10 | IPR013799 | 1 | 121 | 7.50e-47 | STAT transcription factor, protein interaction |
NP_009330 | Gene3D | G3DSA:1.20.1050.20 | IPR013800 | 137 | 317 | 1.10e-68 | STAT transcription factor, all-alpha |
NP_009330 | Gene3D | G3DSA:2.60.40.630 | IPR012345 | 318 | 460 | 7.40e-66 | STAT transcription factor, DNA-binding, subdomain |
NP_009330 | Gene3D | G3DSA:3.30.505.10 | IPR000980 | 582 | 711 | 5.80e-53 | SH2 domain |
NP_009330 | PANTHER | PTHR11801 | IPR001217 | 2 | 750 | 0.00e-00 | Transcription factor STAT |
NP_009330 | Pfam | PF00017 | IPR000980 | 578 | 638 | 6.80e-09 | SH2 domain |
NP_009330 | Pfam | PF01017 | IPR013800 | 137 | 315 | 1.10e-64 | STAT transcription factor, all-alpha |
NP_009330 | Pfam | PF02864 | IPR013801 | 317 | 567 | 4.40e-120 | STAT transcription factor, DNA-binding |
NP_009330 | Pfam | PF02865 | IPR013799 | 2 | 121 | 3.40e-43 | STAT transcription factor, protein interaction |
NP_009330 | Pfam | PF12162 | IPR022752 | 715 | 739 | 4.20e-12 | Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal |
NP_009330 | ProSiteProfiles | PS50001 | IPR000980 | 573 | 670 | 0.00e-00 | SH2 domain |
NP_009330 | SMART | SM00252 | IPR000980 | 575 | 687 | 1.10e-03 | SH2 domain |
NP_009330 | SMART | SM00964 | IPR013799 | 2 | 122 | 1.20e-66 | STAT transcription factor, protein interaction |
NP_009330 | SUPERFAMILY | SSF47655 | IPR015988 | 134 | 317 | 0.00e-00 | STAT transcription factor, coiled coil |
NP_009330 | SUPERFAMILY | SSF48092 | IPR013799 | 1 | 121 | 0.00e-00 | STAT transcription factor, protein interaction |
NP_009330 | SUPERFAMILY | SSF49417 | IPR008967 | 317 | 568 | 0.00e-00 | p53-like transcription factor, DNA-binding |
Pfam Annotation | ||||
Protein | Pfam ID | E.value | Name | Description |
NP_009330 | PF01017 | 0 | STAT_alpha | STAT protein, all-alpha domain |
NP_009330 | PF02864 | 0 | STAT_bind | STAT protein, DNA binding domain |
NP_009330 | PF02865 | 3.40516e-43 | STAT_int | STAT protein, protein interaction domain |
NP_009330 | PF12162 | 1.7e-12 | STAT1_TAZ2bind | STAT1 TAZ2 binding domain |
NP_009330 | PF00017 | 8.9e-10 | SH2 | SH2 domain |
Gene Ontology Annotation | |||
Protein | Entry | Name Space | Description |
NP_009330 | GO:0006357 | biological_process | regulation of transcription from RNA polymerase II promoter |
NP_009330 | GO:0045893 | biological_process | positive regulation of transcription, DNA-templated |
NP_009330 | GO:0060397 | biological_process | JAK-STAT cascade involved in growth hormone signaling pathway |
NP_009330 | GO:0005634 | cellular_component | nucleus |
NP_009330 | GO:0005737 | cellular_component | cytoplasm |
NP_009330 | GO:0003677 | molecular_function | DNA binding |
NP_009330 | GO:0004871 | molecular_function | signal transducer activity |
NP_009330 | GO:0005509 | molecular_function | calcium ion binding |
NP_009330 | GO:0019901 | molecular_function | protein kinase binding |