Basic Information
Gene ID 6932 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name TCF7; TCF1
Full Name Transcription factor 7
Organism Homo sapiens [9606]

Cross Reference
UniProt P36402 UniGene Hs.573153
PDB NULL OMIM 189908
KEGG hsa:6932 UCSC uc003kza.3

Protein Interactions
DIP NULL
IntAct P36402
MINT MINT-1779551
STRING 9606.ENSP00000340347

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000326540 Gene3D G3DSA:1.10.30.10 IPR009071 268 348 1.60e-28 High mobility group box domain
ENSP00000326540 Gene3D G3DSA:4.10.900.10 IPR027397 1 64 5.50e-24 Catenin binding domain
ENSP00000326540 PANTHER PTHR10373 IPR024940 1 366 0.00e-00 Transcription factor TCF/LEF
ENSP00000326540 PANTHER PTHR10373:SF27 IPR028785 1 366 0.00e-00 Transcription factor 7
ENSP00000326540 Pfam PF00505 IPR009071 269 336 1.10e-21 High mobility group box domain
ENSP00000326540 Pfam PF08347 IPR013558 1 212 4.90e-49 CTNNB1 binding, N-teminal
ENSP00000326540 ProSiteProfiles PS50118 IPR009071 269 337 0.00e-00 High mobility group box domain
ENSP00000326540 SMART SM00398 IPR009071 268 338 3.40e-24 High mobility group box domain
ENSP00000326540 SUPERFAMILY SSF47095 IPR009071 268 347 0.00e-00 High mobility group box domain

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000326540 PF08347 0 CTNNB1_binding N-terminal CTNNB1 binding
ENSP00000326540 PF00505 1.1e-21 HMG_box HMG (high mobility group) box
ENSP00000326540 PF09011 5.7e-08 HMG_box_2 HMG-box domain

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000326540 GO:0060070 biological_process canonical Wnt signaling pathway
ENSP00000326540 GO:0005634 cellular_component nucleus
ENSP00000326540 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSP00000326540 GO:0008013 molecular_function beta-catenin binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
10116 Rattus norvegicus 363595 8128 Oreochromis niloticus 100710520
9597 Pan paniscus 100980839 9555 Papio anubis 101024089
39432 Saimiri boliviensis 101029076 28377 Anolis carolinensis ENSACAG00000002732
9646 Ailuropoda melanoleuca ENSAMEG00000017798 9615 Canis familiaris ENSCAFG00000000990
10141 Cavia porcellus ENSCPOG00000020029 9361 Dasypus novemcinctus ENSDNOG00000012979
10020 Dipodomys ordii ENSDORG00000005128 9796 Equus caballus ENSECAG00000008098
9365 Erinaceus europaeus ENSEEUG00000010996 9371 Echinops telfairi ENSETEG00000007556
9685 Felis catus ENSFCAG00000008424 9595 Gorilla gorilla ENSGGOG00000008257
9785 Loxodonta africana ENSLAFG00000016828 9103 Meleagris gallopavo ENSMGAG00000008458
30608 Microcebus murinus ENSMICG00000017587 59463 Myotis lucifugus ENSMLUG00000006530
9544 Macaca mulatta ENSMMUG00000022788 9669 Mustela putorius furo ENSMPUG00000010174
9986 Oryctolagus cuniculus ENSOCUG00000015935 9978 Ochotona princeps ENSOPRG00000006619
9813 Procavia capensis ENSPCAG00000009973 9601 Pongo abelii ENSPPYG00000015782
9598 Pan troglodytes ENSPTRG00000017236 42254 Sorex araneus ENSSARG00000008276
9305 Sarcophilus harrisii ENSSHAG00000016841 43179 Ictidomys tridecemlineatus ENSSTOG00000010550
37347 Tupaia belangeri ENSTBEG00000015456 59729 Taeniopygia guttata ENSTGUG00000001295
9739 Tursiops truncatus ENSTTRG00000016857 8364 Xenopus tropicalis ENSXETG00000016100
8083 Xiphophorus maculatus ENSXMAG00000008260 9315 Macropus eugenii ENSMEUG00000004184
13616 Monodelphis domestica ENSMODG00000014163 9258 Ornithorhynchus anatinus ENSOANG00000011198
30611 Otolemur garnettii ENSOGAG00000024343 132908 Pteropus vampyrus ENSPVAG00000012426
9823 Sus scrofa ENSSSCG00000030680 9478 Tarsius syrichta ENSTSYG00000010484