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Gene 1 | Gene 2 | Interaction Type | Sentence | Value | Judge me |
MAPK | p38 | associate1 | Mitogen-activated protein kinase ( MAPK ) signaling cascades trigger stimulus-specific responses in cells with ERK being associated with proliferation and differentiation , and JNK SAPK and p38 media | 70 | good bad |
MAPK | rho | bind1 | Because p65PAK is known to be upstream of p38MAPK and also be a target of p21rac-1 , which belongs to the rho subfamily of p21ras-related small GTP-binding proteins , these results strongly suggested | 22 | good bad |
MAPK | lipoxygenase | bind3 | The oxidized lipid and lipoxygenase product 12 ( S ) -hydroxyeicosatetraenoic acid induces hypertrophy and fibronectin transcription in vascular smooth muscle cells via p38 MAPK and cAMP response elem | 16 | good bad |
MAPK | PKC | complex2 | Together , the data suggest that DA activated MAPK ERK via Ras , Raf-1 kinase , and DAG-dependent PKC isoenzymes , but , importantly and contrary to the classical model , this pathway did not involve | 15 | good bad |
MAPK | Erk | associate3 | However , while pretreatment of U937 cells with the kinase inhibitors PD98059 and SB203580 abrogated the osmotic activation of Erk and p38 MAPK , respectively , it did not prevent the associated stimu | 10 | good bad |
MAPK | ERK1 | bind3 | These results suggest that the nPKC isoforms produce a unique shift in MAPK activity , via a Ras , MEKK1 , MEK3 pathway , to increase p38delta and inhibit ERK1 2 , and ultimately increase C EBPalpha | 9 | good bad |
MAPK | Ras | bind1 | The Ras family of GTP-binding proteins are key transducers of extracellular signals , particularly through the mitogen-activated protein kinase ( MAPK ) pathway . | 9 | good bad |
MAPK | blr1 | complex2 | Upstream signaling requirements of retinoic acid ( RA ) -induced blr1 expression and downstream signaling consequences of blr1 over-expression in a human myeloid leukemia cell line demonstrate that mi | 6 | good bad |
mapk | JNK | complex1 | The inhibitory effect of p38 ( mapk ) appears more complex and may be due to the ability of p38 ( mapk ) to inhibit LPS-induced JNK activation . | 5 | good bad |
MAPK | PKA | complex1 | CONCLUSION : These findings show that the stimulation of NO production by IL-17 is mediated mainly by a complex activation of kinases , especially PKA , NF-kappaB , and MAPK . | 5 | good bad |
MAPK | calcineurin | associate3 | Recently many reports have revealed that calcineurin and stress activated protein kinase ( SAPK ) p38-mitogen activated protein kinase ( MAPK ) hypertrophic signalling pathways are associated with th | 4 | good bad |
MAPK | CREB | bind1 | Here , we have investigated the effects of stress on the expression of three members of the MAPK extracellular-regulated kinase ( ERK ) pathway such as phospho-ERK1 , phospho-ERK2 and phospho-cAMP c | 4 | good bad |
MAPK | CREB | bind1 | Transfection with dominant negative ( dn ) forms of CREB and C EBP , the two CRE-binding transcription factors targeted by the p38 MAPK pathway , resulted in opposite effects i . | 4 | good bad |
MAPK | ERK | bind1 | A docking domain in extracellular-signal-regulated kinase ( ERK ) , a MAPK , serves as a common site for binding to the MAPK kinase MEK1 , the MAPK-activated protein kinase MNK1 and the MAPK phosphata | 4 | good bad |
MAPK | HOG1 | complex2 | The recent discovery of two other MAPK subtypes , the JNK SAPK subfamily and p38 RK ( mammalian equivalents of HOG1 in yeast ) , reveals extreme complexity within the family and , most intriguingly | 4 | good bad |
MAPK | plasmin | bind3 | Here we demonstrate that in human primary monocytes plasmin stimulates mitogen-activated protein kinase ( MAPK ) signaling via phosphorylation of MAPK kinase ( MKK ) 3 6 and p38 MAPK that triggers su | 4 | good bad |
MAPK | ANG | interact3 | The molecular mechanism ( s ) of insulin action is mediated , at least in part , via interaction of the functional IRE with unidentified 48- and 70- kDa nuclear proteins in the rat ANG gene and is MAP | 3 | good bad |
MAPK | AP-1 | bind1 | This Lf-induced AP-1 DNA binding activity was reduced by a p38 MAPK inhibitor . | 3 | good bad |
MAPK | EGFR | bind1 | The EGFR is a receptor tyrosine kinase , and after binding of its ligand , it triggers several intracellular signaling cascades , among them the one activating the mitogen-activated protein kinases ( | 3 | good bad |
MAPK | Epo | bind1 | In FDCER cell lines , which express endogenous c-Kit , the signaling capacities of such minimal Epo receptor forms ( ER-HY343 and ER-HY343F ) have been dissected to reveal : 1 ) that Epo-dependent mit | 3 | good bad |
MAPK | p42 | complex1 | This tethered receptor complex enables coincident integrative signalling to p42 p44 MAPK . | 3 | good bad |
MAPK | Bad | associate2 | These effects were blocked by U0126 , a mitogen-activated protein kinase Erk kinase 1 2 inhibitor , suggesting an association between Bad phosphorylation and MAPK activation . | 2 | good bad |
MAPK | ERK1 | bind3 | These results suggest that the nPKC isoforms produce a unique shift in MAPK activity , via a Ras , MEKK1 , MEK3 pathway , to increase p38delta and inhibit ERK1 2 , and ultimately increase C EBPalpha | 2 | good bad |
MAPK | PI | interact3 | The interactions between the phosphatidylinositol 3-kinase ( PI 3-kinase ) and Ras MAPK kinase pathways have been the subject of considerable interest . | 2 | good bad |
MAPK | IKK | interact2 | Kinase assays indicated that ATA inhibited IkappaB kinase ( IKK ) , extracellular signal-regulated kinase ( ERK ) , and p38 mitogen-activated protein kinase ( MAPK ) activity both in vivo and in vitro | 1 | good bad |
MAPK | JNK | complex2 | The upstream JNK activators apoptosis signal-regulating kinase 1 ( ASK1 ) and mitogen-activated protein kinase ( MAPK ) kinase 4 were also found in complex with beta-arrestin 2 . | 1 | good bad |
MAPK | JNK | complex2 | Wortmannin-mediated activation of the SAPK JNK and p38 MAPK pathways also resulted in the mobilization of activator protein-1 complex to the nuclear compartment . | 1 | good bad |
MAPK | Trk | bind1 | Although a previous study suggested that ShcB and ShcC do not strongly interact with the Trk receptors ( 1 ) , we find that ShcB and ShcC bind the Trk receptors in a phosphotyrosine dependent manner v | 1 | good bad |
MAPK | CBP | bind1 | Here we show that transcriptional activation of an AP1-regulated gene through the mitogen-activated protein kinase ( MAPK ) -extracellular signal-regulated kinase ( ERK ) pathway ( MAPK ( ERK ) ) is c | 0 | good bad |
MAPK | ERK | associate3 | Contrary to our expectations , ERK and JNK , the MAPK pathways traditionally associated with cell growth and perhaps malignant transformation , were not consistently activated in the human lung tumor | 0 | good bad |
MAPK | rin | interact1 | Mutations in rin G3BP genetically interact with components of the Ras signaling pathway that function at the level of Ras and above , but not with Raf MAPK pathway components . | 0 | good bad |
MAPK | tau | associate1 | These findings indicate that MAPK ERK-P , SAPK JNK-P and p-38-P are differentially expressed in association with tau deposits in tauopathies . | 0 | good bad |
MAPK | RXR | bind1 | How IL-1beta signaling leads to reduced RXR : RAR nuclear binding activity is unknown , and we sought to determine if mitogen activated protein kinase ( MAPK ) pathways were involved . | -1 | good bad |
MAPK | ang | bind1 | Co-incubation with ang II and high glucose had no additive effect on TGF-beta1 promoter activity , protein binding to the AP-1 box B or activation of p38 MAPK . | -2 | good bad |
MAPK | JNK | interact1 | Stress-activated protein kinase ( SAPK ) pathway-regulating phosphatase 1 ( SKRP1 ) has been identified as a member of the mitogen-activated protein kinase ( MAPK ) phosphatase ( MKP ) family that int | -2 | good bad |
MAPK | MK2 | bind1 | Mitogen-activated protein kinase ( MAPK ) -activated protein kinase 2 ( MK2 ) is activated upon stress by p38 MAPKalpha and -beta , which bind to a basic docking motif in the C terminus of MK2 and whi | -2 | good bad |
MAPK | TFI | interact3 | In these cells , the physical interaction between COUP-TFI and hERalpha increases the affinity of hERalpha for ERK2 p42 ( MAPK ) , resulting in an enhanced phosphorylation state of the hERalpha Ser11 | -2 | good bad |
MAPK | PI | associate3 | Thrombin-mediated MAPK activation was modulated by PI-PLC , Ca2 + , PKC , tyrosine kinase , and PI 3-kinase associated with cell proliferation in canine cultured TSMCs . | -3 | good bad |
MAPK | AP-1 | bind1 | The AP-1 complex contained phosphorylated c-Jun and ATF2 and its DNA binding activity was blocked by the p38 MAPK inhibitor SB203580 . | -4 | good bad |
MAPK | p42 | bind2 | Binding of chemokines to their receptors on leukocytes leads to the activation of heterotrimeric G proteins that initiate multiple signaling cascades , including p38 and p42 p44 mitogen-activated pro | -4 | good bad |
MAPK | JNK | interact1 | Stress-activated protein kinase ( SAPK ) pathway-regulating phosphatase 1 ( SKRP1 ) has been identified as a member of the mitogen-activated protein kinase ( MAPK ) phosphatase ( MKP ) family that int | -5 | good bad |
MAPK | Myt1 | interact1 | We have found that Myt1 is likely to be the Mos target in this process , as Mos interacts with Myt1 in oocyte extracts and Mos triggers Myt1 phosphorylation on some sites in vivo , even in the absence | -13 | good bad |
MAPK | MUK | bind1 | MAPK upstream kinase ( MUK ) -binding inhibitory protein , a negative regulator of MUK dual leucine zipper-bearing kinase leucine zipper protein kinase . | -17 | good bad |
MAPK | PTEN | interact3 | Interactions of PPARgamma with X-RARalpha , protein kinase R ( PKR ) , PTEN , and mitogen-activated protein kinase ( MAPK ) have been described . | -51 | good bad |
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Text2Knowledge ... Yong Huang
2002
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