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Gene 1 Gene 2 Interaction Type Sentence Value Judge me
BRCA1 topoisomerase bind1 We have previously shown that the BRCT regions of TopBP1 ( DNA topoisomerase II binding protein 1 ) and BRCA1 bound DNA breaks . 30 good bad
Brca1 Brca2 associate3 Furthermore , the breast cancer-associated proteins Brca1 and Brca2 , the Fanconi anemia-associated FANC proteins , and cell cycle checkpoint proteins are involved in regulating the cellular response 17 good bad
BRCA1 BRCA2 associate3 The purpose of this report is to review the current state of knowledge of BRCA1 and BRCA2 , the biology of associated tumors , and possible risk reduction strategies in women with these deleterious mu 17 good bad
Brca1 Brca2 interact2 Utilizing the yeast two hybrid system and other techniques several other Brca1 and Brca2 interacting proteins have been identified like , BARD1 , importin-alpha , BIPs , RNA polymerase II holoenzyme , 17 good bad
BRCA1 BRG1 interact1 We show that BRCA1 can directly interact with the BRG1 subunit of the SWI SNF complex . 17 good bad
BRCA1 1 interact3 In this study , we demonstrate for the first time the in vitro and in vivo interaction of Elk-1 with BRCA1 splice variants BRCA1a and BRCA1b using GST-pull down assays , co-imunoprecipitations Wester 16 good bad
BRCA1 ATF interact3 Using the yeast two-hybrid system , we identified an interaction between the BRCA1 RING finger and ATF1 , a member of the cAMP response element-binding protein activating transcription factor ( CREB 16 good bad
BRCA1 BARD1 complex2 Although no changes were detected in CstF , BARD1 , and BRCA1 protein levels , increased amounts of a CstF BARD1 BRCA1 complex were detected . 16 good bad
BRCA1 Nmi associate1 Homodimerization of Nmi enhanced its association with BRCA1 . 16 good bad
BRCA1 p27 associate1 Low p27 ( Kip1 ) expression was seen in 110 tumors ( 63 % ) and was significantly associated with BRCA1 2 mutations ( odds ratio , 4 . 16 good bad
BRCA1 AIB1 associate3 Our results support the hypothesis that pathways involving endocrine signaling , as measured through AIB1 genotype and reproductive history , may have a substantial effect on BRCA1 2-associated breas 15 good bad
BRCA1 cadherin associate3 BRCA1 and E-cadherin promoter hypermethylation and gene inactivation in cancer-association or mechanism ? 15 good bad
Brca1 DES interact1 We used mice with a Brca1 mutation on a BALB cJ inbred background ( BALB cB1 + - mice ) or a Brca2 genetic alteration on the 129 SvEv genetic background ( 129B2 + - mice ) to investigate potentia 15 good bad
BRCA1 JAK2 interact1 Immunoprecipitation assay showed that BRCA1 interacted with JAK1 and JAK2 . 15 good bad
BRCA1 LMO4 interact1 The C-terminal BRCT domains of BRCA1 , previously shown to bind CtIP , also mediated interaction with LMO4 . 15 good bad
BRCA1 p300 associate3 Endogenous as well as overexpressed BRCA1 and p300 were found to associate in a phosphorylation-independent manner . 15 good bad
BRCA1 RB bind1 The N-terminal site contains a consensus RB binding motif , LXCXE ( aa 358-362 ) , but the role of this motif in RB binding and BRCA1 functional activity is unclear . 15 good bad
BRCA1 RB bind3 Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding . 15 good bad
BRCA1 ATF1 associate3 We demonstrate that BRCA1 and ATF1 can physically associate in vitro , in yeast , and in human cells . 14 good bad
BRCA1 BAP1 interact1 BAP1 , a candidate tumor suppressor protein that interacts with BRCA1 . 14 good bad
BRCA1 BARD1 associate1 Based on its amino acid sequence and the existence of three nuclear localization signal ( NLS ) 3 regions , BRCA1 is likely to be a cell cycle-dependent nuclear protein , regulated by cyclin-dependent 14 good bad
BRCA1 BARD1 complex1 A subset of the endogenous pool of CtIP polypeptides exists in a protein complex that includes both BRCA1 and the BRCA1-associated RING domain protein ( BARD1 ) . 14 good bad
BRCA1 BARD1 interact1 Each of the BRCA1 Site II mutants still interact and form a stable heterodimer with BARD1 . 14 good bad
BRCA1 BARD1 interact1 We now show that these autoantibodies are directed against BARD1 , originally identified as a protein interacting with the product of the breast cancer gene 1 , BRCA1 . 14 good bad
BRCA1 BARD1 interact2 Moreover , we show that the cleavage site of BARD1 is located NH2 terminally but downstream of the RING domain essential for BARD1 and BRCA1 protein interaction . 14 good bad
BRCA1 BARD1 interact3 Identification of residues required for the interaction of BARD1 with BRCA1 . 14 good bad
BRCA1 BRCA2 associate2 Association between BRCA1 and BRCA2 mutations and cancer phenotype in Spanish breast ovarian cancer families : implications for genetic testing . 14 good bad
BRCA1 BRCA2 associate2 LOH of the 4 loci did not occur independently ; there were highly significant associations between LOH of BRCA1 and both BRCA2 ( p & amp ; # 60 ; 0 . 14 good bad
Brca1 Brca2 associate3 Brca1 and Brca2 null mutants are similar in phenotype : mutations in both genes result in embryonic lethality and the developing embryos show signs of a cellular proliferation defect associated with a 14 good bad
BRCA1 BRCA2 associate3 In the populations studied , breast cancer susceptibility genes other than BRCA1 and BRCA2 either do not exist , are rare , or are associated with low disease penetrance . 14 good bad
BRCA1 BRCA2 associate3 OBJECTIVE : The aim of this pilot study was to screen the major segments of the BRCA1 and BRCA2 genes for disease-associated mutations in Arab and Asian women with breast cancer from the Kingdom of Sa 14 good bad
BRCA1 BRCA2 associate3 The decision to undergo testing for the BRCA1 and BRCA2 mutations , which are associated with an increased risk of breast and ovarian cancer , can have long-term consequences on women ' s lives . 14 good bad
BRCA1 BRCA2 associate3 We investigated cancer incidence between 1958 and 1995 in 1873 individuals belonging to 29 consecutively identified BRCA1 and 20 BRCA2 associated families from Southern Sweden using data from parish a 14 good bad
BRCA1 BRCA2 interact2 Functional characterization of BRCA1 and BRCA2 : clues from their interacting proteins . 14 good bad
BRCA1 BRCA2 interact3 We review the evidence for gene-gene and gene-environment interaction in modifying that risk , and discuss the contribution of BRCA1 and BRCA2 and other high penetrance genes to both inherited and spo 14 good bad
BRCA1 Elk-1 interact1 c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a 1b and enhances BRCA1a 1b-mediated growth suppression in breast cancer cells . 14 good bad
BRCA1 FANCD2 associate1 It activates the downstream protein FANCD2 by monoubiquitylation ; this then forges an association with the BRCA1 protein at sites of DNA damage . 14 good bad
BRCA1 FANCG interact1 These data indicate that cellular resistance to these DNA damaging agents requires FANCG and that the FA gene pathway , via its activation of FANCD2 and that protein ' s subsequent interaction with BR 14 good bad
BRCA1 Fas interact2 Subsequent mapping of the apoptotic pathway induced by growth factor withdrawal demonstrated that BRCA1 enhanced signaling through a pathway that sequentially involved H-Ras , MEKK4 , JNK , Fas ligand 14 good bad
BRCA1 MSH2 associate2 The association of BRCA1 with MSH2 and MSH6 , which are required for transcription-coupled repair , provides a possible explanation for the role of BRCA1 in this pathway . 14 good bad
BRCA1 Nmi associate1 Two mutated forms of BRCA1 , a missense ( A1708E ) and a nonsense ( Y1853X ) that have been identified in familial breast cancers , associated with Nmi and c-Myc but failed to suppress c-Myc-induced h 14 good bad
BRCA1 Nmi associate2 We observed a novel endogenous association of BRCA1 with Nmi ( N-Myc-interacting protein ) in breast cancer cells . 14 good bad
BRCA1 p300 bind1 On the other hand , BRCA1 failed to alter the expression of the CREB binding protein ( CBP ) , the structural and functional homologue of p300 , in any of these cell types . 14 good bad
BRCA1 Rad51 associate3 BRCA1 and BRCA2 proteins form a complex with Rad51 , and these genes are thought to participate in a common DNA damage response pathway associated with the activation of homologous recombination and d 14 good bad
Brca1 Rb bind1 The Brca1 promoter contains E2F DNA-binding sites that mediate transcriptional activation by E2F1 and repression by Rb . 14 good bad
BRCA1 VCP associate1 Here , we demonstrate that the BRCA1 protein physically associates with valosin-containing protein ( VCP ) , a member of the ATPases associated with a variety of cellular activities ( AAA ) superfamil 14 good bad
BRCA1 VCP bind1 In vitro studies revealed that VCP , via its N- terminal region , bi 14 good bad
Brca1 2 associate2 The association between Brca1 status and Bcl-2 expression remained significant after adjustment for the oestrogen receptor status . 13 good bad
BRCA1 adriamycin interact3 Finally , the interaction between CtIP and BRCA1 is shown to be stable in the face of genotoxic stress elicited by treatment with UV light , adriamycin , or hydrogen peroxide . 13 good bad
BRCA1 APC associate1 The frequency of the APC I1307K mutation and its association with disease pattern was examined in 996 Ashkenazi women consisting of individuals with either sporadic ( n = 382 ) or hereditary ( n = 143 13 good bad
BRCA1 ATR interact1 We have shown that ATR can phosphorylate several BRCA1 fragments in vitro and that a kinase-inactive mutant of ATR interacts with BRCA1 in vivo . 13 good bad
BRCA1 BACH1 bind1 Analysis of human BRCA1 tumor-derived mutations and conservation identifies a potential protein-binding site that we show through mutagenesis is involved in BACH1 binding . 13 good bad
Brca1 BACH1 bind1 The 53BP1 tandem-BRCT region is homologous to the tandem-BRCT region of Brca1 , which is involved in double-strand break repair and homologous recombination and which binds BACH1 , a member of the DEA 13 good bad
BRCA1 BACH1 bind3 A BACH1 derivative , bearing a mutation in a residue that was essential for catalytic function in other helicases , interfered with normal double-strand break repair in a manner that was dependent on 13 good bad
BRCA1 BARD1 interact1 Here we report on the structural consequences of such mutations introduced into the second Zn ( 2 + ) site ( Site II ) of the BRCA1 RING domain and their effect on the interaction with the BARD1 RING 13 good bad
BRCA1 BARD1 interact3 The interaction of BARD1 with NF-kappaB , suggests modulation of transcriptional activity independent of BRCA1 . 13 good bad
BRCA1 BARD1 interact3 We discuss the interaction of BRCA1 with the BACH1 and BARD1 proteins , and suggest that the pleiotropic nature of mutations in BRCA1 may be associated with defects in protein--protein interactions . 13 good bad
BRCA1 BRCA2 associate1 In particular , the genes BRCA1 and BRCA2 are associated with a hereditary disposition to breast cancer , and the algorithm is used to find gene sets whose expressions can be used to classify BRCA1 an 13 good bad
BRCA1 BRCA2 associate2 Association between loss of heterozygosity of BRCA1 and BRCA2 and morphological attributes of sporadic breast cancer . 13 good bad
BRCA1 BRCA2 associate2 Expecting a founder effect , we searched for geographical clustering of breast cancer cases and searched for associations between the affected phenotype and shared genomic segments in the BRCA1 and BR 13 good bad
BRCA1 BRCA2 associate3 BACKGROUND : Germline mutations in the BRCA1 and BRCA2 genes are associated with an increased risk of breast cancer . 13 good bad
BRCA1 BRCA2 associate3 Both BRCA1 and BRCA2 large encode proteins that appear to have a plethora of functions , with a conspicuous association to DNA repair and DNA recombination , and probably transcription activation . 13 good bad
BRCA1 BRCA2 associate3 DESIGN AND METHODS : We conducted an extensive literature search of all published articles ( including Medline ) on preclinical data on the function of BRCA1 and BRCA2 , associated tumor pathology , a 13 good bad
BRCA1 BRCA2 associate3 Early onset breast cancer per se is a weak predictor of finding germ line mutation ( s ) in BRCA1 and BRCA2 , unless associated with a positive family history and or bilaterality . 13 good bad
BRCA1 BRCA2 associate3 The present article reviews the current state of knowledge regarding the biology of BRCA1 and BRCA2 , the cancer risks associated with carrying a pathogenic mutation in either of these genes and the p 13 good bad
BRCA1 BRCA2 associate3 These data suggest that the presence of multiple primary cancer of any kind may predict for an increased likelihood of finding a BRCA1 or BRCA2 mutation and supports previous studies suggesting that B 13 good bad
BRCA1 BRCA2 associate3 These include mutations in the genes BRCA1 and BRCA2 , associated with a 10- to 20-fold increased risk of developing breast cancer . 13 good bad
BRCA1 BRCA2 complex1 New complexities for BRCA1 and BRCA2 . 13 good bad
BRCA1 BRCA2 interact2 Also , additional breast cancer genes can be identified by further characterization of the function of BRCA1 and BRCA2 and their interacting proteins . 13 good bad
BRCA1 BRCA2 interact2 The functions of the proteins encoded by BRCA1 and BRCA2 remain to be elucidated , but their interaction and colocalization with hRAD51 suggest a role in homologous recombination and DNA double-strand 13 good bad
BRCA1 BRCA2 interact3 In humans , its interaction with proteins like BRCA1 and BRCA2 has provided an insight into the mechanism of how these molecules function as tumor suppressors . 13 good bad
BRCA1 Brg1 associate1 Besides , the Brg1 gene is silenced or mutated in several tumors cell lines and a Brg1-associated complex was recently found to co-purify with BRCA1 , involved in breast and ovarian cancers . 13 good bad
BRCA1 cadherin associate2 Anti-invasion and migration potentials of the CMTs were associated with an increased expression of E-cadherin catenins ( alpha , beta and gamma-catenin ) and tumor suppressor BRCA1 . 13 good bad
BRCA1 Chk2 bind1 We show that the Chk2 FHA domain mediates ATM-dependent Chk2 phosphorylation and targeting of Chk2 to in vivo binding partners such as BRCA1 through either or both of two structurally distinct mechani 13 good bad
BRCA1 HNPCC interact3 The functional interaction between BRCA1 and hMSH2 may provide a partial explanation for the background of gynecological and colorectal cancer in both HNPCC and BRCA1 kindreds , respectively . 13 good bad
BRCA1 HNPCC interact3 We have identified the physical interaction between the Breast Cancer susceptibility gene product BRCA1 and the Hereditary Non-Polyposis Colorectal Cancer ( HNPCC ) and DNA mismatch repair ( MMR ) gen 13 good bad
BRCA1 Kip1 associate3 In a multivariate analysis , both BRCA1 2 mutation and low p27 ( Kip1 ) expression were associated with a shorter DDFS ( relative risk [ RR ] , 2 . 13 good bad
BRCA1 LMO4 complex1 A stable complex comprising LMO4 , BRCA1 , and CtIP was demonstrated in vivo . 13 good bad
BRCA1 LMO4 interact1 The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity . 13 good bad
BRCA1 LMO4 interact3 Tumor-associated mutations within the BRCT repeats that abolish interaction between BRCA1 and CtIP had no effect on the association of BRCA1 with LMO4 . 13 good bad
BRCA1 mass associate1 We found BRCA1 associated with the RNA polymerase II holoenzyme ( holo-pol ) , a large mass complex called the fraction 5 complex , the Rad50-Mre11-Nbs1 complex , and a complex that has not been descr 13 good bad
BRCA1 MYC bind1 BRCA1-regulated genes associated with breast tumorigenesis included the estrogen-responsive genes MYC and cyclin D1 , which are overexpressed in many breast tumors ; STAT1 and JAK1 , key components of 13 good bad
BRCA1 neu associate1 Our data suggest that a germ-line mutation in the BRCA1 tumor suppressor gene is associated with a significantly lower level of HER-2 neu amplification . 13 good bad
BRCA1 p300 associate3 Immunocolocalization analyses suggest that BRCA1 and p300 associate in a cell cycle-dependent manner . 13 good bad
BRCA1 PK complex1 Three DNA double-strand break repair protein complexes were activated : DNA-dependent protein kinase ( DNA-PK ) , NBS1-MRE11-RAD50 , and BRCA1 . 13 good bad
BRCA1 Rad51 interact1 The protein products of the hereditary breast cancer susceptibility genes , BRCA1 and BRCA2 , interact with the Rad51 protein , a central component of homologous repair pathways . 13 good bad
BRCA1 RB bind1 In both in vitro and in vivo assays , we found that the BRCA1 : RB interaction does not require the BRCA1 LXCXE motif , nor does it require an intact A B binding pocket of RB . 13 good bad
BRCA1 SMC1 associate1 SMC1 associates with BRCA1 and is phosphorylated in response to IR in an ATM- and NBS1-dependent manner . 13 good bad
BRCA1 Sp1 interact3 Functional interactions between BRCA1 and Sp1 in the regulation of the IGF-I-R gene were studied in Schneider cells , a Drosophila cell line which lacks endogenous Sp1 . 13 good bad
BRCA1 SRBC bind1 A cDNA clone encoding human SRBC [ serum deprivation response factor ( sdr ) -related gene product that binds to c-kinase ] was isolated in a yeast two-hybrid screening , with amino acids 1-304 of BRC 13 good bad
BRCA1 TP53 associate1 Recent work has shown that breast cancers occurring in women carrying germ-line BRCA1 mutations tend to have clinicopathological features that are usually associated with a poor prognosis , such as hi 13 good bad
BRCA1 TP53 associate3 CONCLUSIONS : Our findings provide novel evidence that loss of BRCA1 function in human cells activates the p53 DNA damage response pathway and that loss of this pathway , by somatic mutation of TP53 , 13 good bad
BRCA1 ubiquitin complex1 Here we demonstrate that the BRCA1-BARD1 heterodimeric RING finger complex contains significant ubiquitin ligase activity that can be disrupted by a breast cancer-derived RING finger mutation in BRCA1 13 good bad
Brca1 ATR associate1 Moreover , ATR associates with Brca1 ; ATR and Brca1 foci co-localize both in cells synchronized in S phase and after exposure of cells to DNA-damaging agents . 12 good bad
BRCA1 BACH1 bind1 BACH1 binds directly to the BRCT repeats of BRCA1 . 12 good bad
BRCA1 BACH1 interact1 BACH1 , a novel helicase-like protein , interacts directly with BRCA1 and contributes to its DNA repair function . 12 good bad
BRCA1 BACH1 interact1 BRCA1 interacts in vivo with a novel protein , BACH1 , a member of the DEAH helicase family . 12 good bad
BRCA1 BARD1 bind1 The breast and ovarian cancer predisposition gene product BRCA1 , binds to BARD1 at its N terminus . 12 good bad
Brca1 Bard1 interact1 Bard1 ( Brca1-associated ring domain ) is a protein interacting with Brca1 and thought to be involved in Brca1-mediated tumor suppression . 12 good bad
Brca1 bcl-2 associate3 bcl-2 might thus be one of the target genes involved in the oncogenesis related to Brca1 and its down-regulation may account for the increased apoptosis and the high proliferative rate observed in Brc 12 good bad
BRCA1 BRCA2 associate1 A third approach , using BRCA1 and BRCA2 mutation carriers to identify genes that are associated with modification of breast cancer risk has met with some limited success , perhaps because effects on 12 good bad
BRCA1 BRCA2 associate2 In order to examine genetic alterations associated with early-onset breast cancer , 31 patients with no known family history , aged 26-35 years at diagnosis , were examined for loss of heterozygosity 12 good bad
BRCA1 BRCA2 associate3 PURPOSE : There is increasing evidence that BRCA1 and BRCA2 associated tumors may differ from sporadic cancers . 12 good bad
BRCA1 BRCA2 associate3 Several lines of evidence indicate that germline mutations in BRCA1 and BRCA2 might be associated with an increased risk for CaP . 12 good bad
BRCA1 BRCA2 associate3 To estimate the proportion of ovarian cancers attributable to founding mutations in BRCA1 and BRCA2 in the Jewish population and the familial cancer risks associated with each , we interviewed 213 Jew 12 good bad
BRCA1 BRCA2 associate3 [ Function of BRCA1 and BRCA2 genes associated with hereditary predisposition to breast cancer ] 12 good bad
BRCA1 BRCA2 complex1 Our results indicate that complex genetic alterations are operational at the BRCA1 and BRCA2 loci in tumors from genetically predisposed individuals . 12 good bad
BRCA1 BRCA2 interact1 Recent studies suggest that BRCA1 interacts with a great variety of proteins , including BRCA2 , cell-cycle regulators , transcriptional activators and repressors . 12 good bad
BRCA1 catenin associate2 Moreover , the promotion of invasion and migration potential by alcohol was associated with the significant decrease of E-cadherin , alpha , beta , and gamma three major catenin , and BRCA1 expression 12 good bad
BRCA1 CBP interact1 BRCA1 interacts with the cAMP response element binding protein ( CREB ) domain of p300 CBP via both its amino and carboxyl termini . 12 good bad
BRCA1 CBP interact1 CBP p300 interact with and function as transcriptional coactivators of BRCA1 . 12 good bad
Brca1 ECM associate2 In a primary cell culture model , association of a laminin-rich extracellular matrix ( ECM ) with mammary epithelial cells was required for cell survival and cell differentiation and suppressed Brca1 12 good bad
BRCA1 GADD45 bind1 Such protein interactions are required for interaction of BRCA1 with the GADD45 promoter because either immunodepletion of Oct-1 and NF-YA proteins or mutations in the OCT-1 and CAAT motifs disrupt BR 12 good bad
BRCA1 GADD45 interact1 BRCA1 also directly interacts with proteins of the DNA repair machinery and regulates expression of both the p21 and GADD45 genes . 12 good bad
BRCA1 glucocorticoid interact1 In addition , BRCA1 was shown to interact physically with both the AR and the p160 coactivator , glucocorticoid receptor interacting protein 1 . 12 good bad
BRCA1 glucocorticoid interact2 , reversed ) the BRCA1 inhibition of ER-alpha activity , whereas two other nuclear receptor coactivators , the p300 CBP-associated factor ( PCAF ) and the glucocorticoid receptor-interacting protein- 12 good bad
BRCA1 histone associate1 We hypothesized that aberrant cytosine methylation of the BRCA1 promoter was associated with the transcriptionally repressive effects of histone hypoacetylation and chromatin condensation . 12 good bad
BRCA1 Kip1 associate1 CONCLUSION : In this study , we showed that BRCA1 2 mutations were associated with low levels of p27 ( Kip1 ) in breast cancer . 12 good bad
BRCA1 MSH2 associate1 In S phase nuclei , p53 foci almost completely colocalize with MSH2 foci and associate with the recombination surveillance factor BRCA1 in irradiated S phase cells . 12 good bad
BRCA1 MSH2 associate1 In S phase nuclei , p53 foci almost completely colocalize with MSH2 foci and associate with the recombination surveillance factor BRCA1 in irradiated S phase cells . 12 good bad
BRCA1 RB interact1 The tumor suppressor activity of the BRCA1 gene product is due , in part , to functional interactions with other tumor suppressors , including p53 and the retinoblastoma ( RB ) protein . 12 good bad
BRCA1 Smad2 interact1 Here we identify Xenopus Swift , a novel nuclear BRCT ( BRCA1 C-terminal ) domain protein that physically interacts with Smad2 via its BRCT domains . 12 good bad
BRCA1 Sp1 interact3 BRCA1 suppresses insulin-like growth factor-I receptor promoter activity : potential interaction between BRCA1 and Sp1 . 12 good bad
BRCA1 adenosine interact3 Moreover , the interaction of BRCA1 with purified hMSH2-hMSH6 appears to be modulated by adenosine nucleotide much like G protein downstream interaction signaling is modulated by guanosine nucleotide 11 good bad
BRCA1 ATF1 interact1 BRCA1 physically and functionally interacts with ATF1 . 11 good bad
BRCA1 BRCA2 associate3 BACKGROUND : The contribution of BRCA1 and BRCA2 to the incidence of male breast cancer ( MBC ) in the United Kingdom is not known , and the importance of these genes in the increased risk of female b 11 good bad
BRCA1 BRCA2 complex1 IMPLICATIONS FOR NURSING PRACTICE : Nurses need to be aware of the complex issues surrounding testing for BRCA1 and BRCA2 mutations and prophylactic mastectomy to be able to provide current informatio 11 good bad
BRCA1 histone interact1 BRCA1 contains several functional domains that interact directly or indirectly with a variety of molecules , including tumor suppressors ( p53 , RB , BRCA2 and ATM ) , oncogenes ( c-Myc , casein kinas 11 good bad
BRCA1 HR interact1 BRCA1 is critical for the maintenance of genomic stability , in part , through its interaction with the Rad50 Mre11 Nbs1 complex , which occupies a central role in DNA double-strand break ( DSB ) re 11 good bad
BRCA1 Jun interact1 Here , it is shown that BRCA1 interacts with Jun proteins via a coiled-coil motif in AD1 and the basic leucine zipper ( bZIP ) region of the Jun proteins . 11 good bad
BRCA1 LMO4 complex1 These findings reveal a novel complex between BRCA1 , LMO4 , and CtIP and indicate a role for LMO4 as a repressor of BRCA1 activity in breast tissue . 11 good bad
BRCA1 Nmi interact1 Nmi was found to interact specifically with BRCA1 , both in vitro and in vivo , by binding to two major domains in BRCA1 , amino acid residues 298-683 and 1301-1863 . 11 good bad
BRCA1 VCP interact1 VCP , a weak ATPase involved in multiple cellular events , interacts physically with BRCA1 in the nucleus of living cells . 11 good bad
BRCA1 XRCC1 bind3 The BRCT regions of tumor suppressor BRCA1 and of XRCC1 show DNA end binding activity with a multimerizing feature . 11 good bad
BRCA1 Adriamycin interact3 In contrast , no specific interaction was observed between BRCA1 induction and treatment of cells with a range of DNA damaging agents including Cisplatin and Adriamycin . 10 good bad
BRCA1 ATR interact3 Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress . 10 good bad
BRCA1 BARD1 interact1 BARD1 ( BRCA1-associated RING domain ) was identified by yeast two-hybrid screening as a protein interacting with BRCA1 . 10 good bad
BRCA1 BARD1 interact1 The RING domain of the breast and ovarian cancer tumor suppressor BRCA1 interacts with multiple cognate proteins , including the RING protein BARD1 . 10 good bad
BRCA1 BRCA2 associate2 We examined the association between bilateral prophylactic mastectomy and breast cancer risk in women at high risk for breast cancer who also had mutations in BRCA1 and BRCA2 genes . 10 good bad
BRCA1 BRCA2 associate3 Germline mutations in the BRCA1 and BRCA2 genes are associated with approximately 80 % of families with a high incidence of breast and or ovarian cancers ( OMIM database reference numbers : 113705 , 10 good bad
BRCA1 BRCA2 associate3 The increased risk of ovarian cancer is consistent with germline mutations in the BRCA1 and BRCA2 genes , while the risk of soft tissue and bone sarcomas may reflect the association of these tumours w 10 good bad
BRCA1 BRCA2 complex2 BRCA1 and BRCA2 breast cancer susceptibility genes encode proteins , the normal cellular functions of which are complex and multiple , and germ-line mutations in individuals predispose both to breast 10 good bad
BRCA1 CIP1 interact1 Here , we report that BRCA1 interacts with androgen receptor ( AR ) and enhances AR target genes , such as p21 ( ( WAF1 CIP1 ) ) , that may result in the increase of androgen-induced cell death in pr 10 good bad
BRCA1 FANCD2 complex2 In male meiosis , FANCD2 also co-localizes with BRCA1 at synaptonemal complexes . 10 good bad
BRCA1 progesterone associate2 There was no significant association between BRCA1 mRNA expression and clinicopathological factors such as menstrual status , tumor size , lymph node status , estrogen and progesterone receptor status 10 good bad
BRCA1 TP53 associate1 Recent work has shown that breast cancers occurring in women carrying germ-line BRCA1 mutations tend to have clinicopathological features that are usually associated with a poor prognosis , such as hi 10 good bad
BRCA1 BARD1 associate1 The BRCA1 RING element mediates nuclear import via association with BARD1 , and this is not affected by cancer-associated RING mutations . 9 good bad
BRCA1 BRCA2 associate1 BRCA1 mutations are more commonly associated with ovarian cancer than BRCA2 mutations . 9 good bad
BRCA1 HR interact1 BRCA1 is critical for the maintenance of genomic stability , in part , through its interaction with the Rad50 Mre11 Nbs1 complex , which occupies a central role in DNA double-strand break ( DSB ) re 9 good bad
Brca1 Rad51 associate1 Our results demonstrate that full-length murine Brca1 is identical to human BRCA1 with respect to its cell cycle regulation , DNA damage-induced phosphorylation , nuclear localization , and associatio 9 good bad
BRCA1 TP53 associate3 A worse clinical outcome in early-onset LOH related cancers emerged from follow-up data : TP53 and BRCA1 LOH were associated with a shorter relapse free interval ( RFI ) ( p = 0 . 7 good bad
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Text2Knowledge ... Yong Huang 2002