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EGFR
OMIM | GENE CARDS | CGAP |
131550 | EGFR | 77432 |
SYNONYMS | ERBB |
epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog) |
Chromosome Human
Chromosomal localisation of the human homologues to the oncogenes erbA and B. Spurr-N-K. Solomon-E. Jansson-M. Sheer-D. Goodfellow-P-N. Bodmer-W-F. Vennstrom-B. EMBO-J 3: 159-163 (1984)
Chromosome Mouse
Erbb is linked to the alpha-globin locus on mouse chromosome 11 Silver-J. Whitney-J-B 3d. Kozak-C. Hollis-G. Kirsch-I. Mol-Cell-Biol 5: 1784-1786 (1985)
Cellular homologs of the avian erythroblastosis virus erb-A and erb-B genes are syntenic in mouse but asyntenic in man Zabel-B-U. Fournier-R-E. Lalley-P-A. Naylor-S-L. Sakaguchi-A-Y. Proc-Natl-Acad-Sci-U-S-A 81: 4874-4878 (1984)
Clinical
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Complementation
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DNA Structure
Wild-type human p53 activates the human EGFR promoter. Deb SP. Munoz RM. Brown DR. Subler MA. Deb S. Oncogene 9: 1341-1349 (1994)
Function
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Gene Frequency Normal
The erbB oncogenes as prognostic markers in oral squamous cell carcinomas Werkmeister R. Brandt B. Joos U Am J Surg 172: 681-3 JC (1996)
Gene Frequency Tumor
Homologue
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling Lowenstein-E-J. Daly-R-J. Batzer-A-G. Li-W. Margolis-B. Lammers-R. Ullrich-A. Skolnik-E-Y. Bar-Sagi-D. Schlessinger-J. Cell 70: 431-42 (1992)
Oncogenic Activation
Analysis of gene amplification in head-and-neck squamous-cell carcinoma Leonard JH. Kearsley JH. Chenevix-Trench G. Hayward NK Int J Cancer 48: 511-515 (1991)
Oncogenicity
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Regulation
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Signaling Pathway
Torso required for embryonic pattern formation, shares substrates with the sevenless and EGF-R pathways Doyle-H-J. Bishop-J-M. Genes-Dev 7: 633-646 (1993)
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