[BiO BB] overlapping/shadow genes in prokaryotes
Timothy Driscoll
molvisions at mac.com
Wed Dec 14 13:41:57 EST 2005
hi,
how prevalent is gene overlap in prokaryote genomes? not just a few
codons at one end, but large regions of overlap, sometimes as long as
the complete gene. I have recently begun curating the genome of a
Gram-negative bacteria. I am finding a lot of predicted overlapping
genes (Genemark, Glimmer, RefSeq), often with roughly equivalent
supporting evidence in favor of both genes (Blast hits, RBS, codon
bias, etc.).
I have been told that overlapping genes are uncommon, and never more
than about 30 codons in the overlap. but I am unable to find any data
to support this. can anyone please provide some helpful references?
many thanks,
tim
--
Timothy Driscoll em: molvisions at mac.com
molvisions - see. grasp. learn. ph: 919-368-2667
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