[BiO BB] Is there a good way to find orthologue sequences?

[Corentin Cras-Méneur]

À 01:49 +0800 le 06/18/05, <yezhiqiang at gmail.com> a écrit:
>Dear all,
>     Is there a good way to find orthologue sequences? I mean, I have a
>protein sequence in species A, how could I get all the available
>corresponding sequences from other species?  I blast my sequence to
>nr, there are just too many hits with low e-value and high identity,
>so that some "corresponding" sequences from distant related species
>could not be find by blast. Is there any good method for automatically
>solve this problem?

You can always download Homologene from the NCBI. 
If you have the Unigene or LocusLink IDs for your 
genes, you can easily find the already annotated 
orthologs through Homologene.

It's all on the FTP server of the NCBI if I quite remember.


Corentin