[BiO BB] proteins related to a particular disease/condition

John G. Hoey, Ph.D. drjohn08318 at yahoo.com
Sun Mar 14 15:28:33 EDT 2010

Unless I'm mistaken, Pankaj had asked for sources on up and down-regulated proteins, not genes.  I frequently make use of the information in the Geo datasets to target genes encoding proteins whose expression might be changed under a set of experimental conditions.  However, it is important to keep in mind there is often no correlation between changes in gene expression (as presented in such microarray datasets) and protein levels.  As long as these caveats are kept in mind, such datasets represent a good jumping off point for identifying proteins of potential relevance to your particular experiment.

John G. Hoey, Ph.D.

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On Mar 14, 2010, at 10:51, Maximilian Haussler <maximilianh at gmail.com> wrote:

I assume that you either have to read papers for this (google: microarray
hypoxia upregulated genes) and then get their supplemental data or do bit of
digging in NCBI GEO. Here is a hypoxia dataset in geo that I've found by
searching geo for hypoxia:


I think nextbio has already processed the data in the way that you need but
it's a company and I don't know which part you can use for free is you're a

good luck
Maximilian Haussler
Tel: +447542993736 +447574054746

On Tue, Mar 9, 2010 at 6:34 AM, Pankaj Khurana <pkhurana08 at gmail.com> wrote:

Hi all,

I would like to get a list of all proteins that are
upregulated/downregulated during hypoxia.
How can I get a list of these proteins?

Thanking all in advance
Dr. Pankaj Khurana
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