Hi Michael. As Joe has done, I would point you to Pise, perhaps the best known Web interface for bioinformatic applications. And I will add BioMOBY to that (http://www.biomoby.org/), which is more infrastructure-related. Catherine Letondal is involved in both projects, BTW. I'll also mention my own project, since it matches your description. Piper (http://bioinformatics.org/piper/) began back in 1998 with a lot of the same goals as BioMOBY and MyGrid. I gave a presentation about it at BOSC 2000. The original concept also very closely matches that of SciCraft (http://www.scicraft.org/), Taverna (http://taverna.sourceforge.net/) (part of MyGrid) and the commercial application VIBE, from Incogen. But, these are native desktop applications. Scaled-back goals will make the new Piper (to be renamed "Pipet") a Web-based system. Please see the website for more information. Cheers. Jeff -- J.W. Bizzaro Bioinformatics Organization, Inc. (Bioinformatics.Org) E-mail: jeff@bioinformatics.org Phone: +1 508 890 8600 --