Hi Ahmed, I have personal experience with Mac clusters and I just finished building a moderately sized cluster built from the Sun Fire X2100 M2 systems. I've not used Dell rackmounts in a very long time but not for any negative reasons. My personal recommendation is to pass on Apple for now -- the Intel Xserves are a few CPU generations behind now and it seems the new focus of Apple as a consumer products company means that they are not really focusing on "enterprise" products meant for datacenters any more. The only alternative I'd say with Apple if you are thinking about a smaller cluster would be to build one from their workstation/ desktop line which does track the modern Intel releases pretty closely. The Sun Fire X2100 M2 machines were fantastic, the remote management ILOM processor is great and allowed us to configure and build the cluster remotely using nothing but VPN and SSH clients. If you go the Dell route, consider paying extra for the Dell version of the remote management card (I think they call it a 'DRAC' ? ) Another hint -- wait until mid-November or later to really nail down your purchase. The SuperComputing 2007 show is coming up shortly and there are going to be some interesting things and new products released at that show. You'll also start to see the quad-core/quad- CPU motherboards show up in vendor products -- 16 cores in a single chassis may be interesting for the type of work you are doing. -Chris On Oct 19, 2007, at 6:23 PM, Ahmed Moustafa wrote: > Thank you so much Chris! > > By "genome-wide", it is more like performing the same task (e.g. > blast, clustalw and phyml) for every single gene in a genome. But > because a single task could include +200 sequences to align or to > build a phylogeny, it takes a significant amount of time and memory > to process a single gene. So by using, for example, mpiblast and > raxmlmpi, it could be possible to distribute these tasks over a > cluster and finish an analysis in a reasonable time. > > I have googled and found these options Dell PowerEdge SC1435 > (http://www.dell.com/content/products/productdetails.aspx/ > pedge_sc1435), Sun Fire X2100 M2 (http://www.sun.com/servers/entry/ > x2100/) and Mac Cluster (http://www.apple.com/science/solutions/ > workgroupcluster.html), do you have an experience with any of these > options? > > Thanks again! > > Ahmed