Thanks to everyone who responded to my query- I now have some very good resources to work with. Frieda Frieda Reichsman, PhD Molecules in Motion Interactive Molecular Structures www.moleculesinmotion.com On May 9, 2005, at 7:07 AM, Paul Pillot wrote: > 1j46 & 1j47 represent the hmg box portion of SRY protein. They only > differ by 1 amino-acid, but the mutation causes a change in shape, > making the protein unable to bend correctly the DNA in order to > initiate the transcription. > > Paul > > Frieda Reichsman a écrit : > >> Dear Colleagues, >> >> I am seeking pdb files to use as paired examples of the effects of a >> single amino acid substitution on protein structure/function. Ideally >> I would like to have some examples of substitutions that alter >> function, and some that have little or no evident functional effect. >> If both types of substitutions are available for the same protein, so >> much the better. >> >> A good example is normal and sickle cell hemoglobin, but I would like >> to have somewhere between four and ten different protein examples. I >> need some that affect binding or enzymatic activity and are located >> in the binding or active site. >> >> Thanks in advance for suggestions on this topic. >> >> Frieda >> > > > _______________________________________________ > Molvis-list mailing list > Molvis-list at bioinformatics.org > https://bioinformatics.org/mailman/listinfo/molvis-list