[Molvis-list] pdb files of wild type/mutants

Frieda Reichsman friedar at nsm.umass.edu
Mon May 9 12:48:21 EDT 2005

Thanks to everyone who responded to my query- I now have some very good 
resources to work with.


Frieda Reichsman, PhD
Molecules in Motion
Interactive Molecular Structures
On May 9, 2005, at 7:07 AM, Paul Pillot wrote:

> 1j46 & 1j47 represent the hmg box portion of SRY protein. They only 
> differ by 1 amino-acid, but the mutation causes a change in shape, 
> making the protein unable to bend correctly the DNA in order to 
> initiate the transcription.
> Paul
> Frieda Reichsman a écrit :
>> Dear Colleagues,
>> I am seeking pdb files to use as paired examples of the effects of a 
>> single amino acid substitution on protein structure/function. Ideally 
>> I would like to have some examples of substitutions that alter 
>> function, and some that have little or no evident functional effect. 
>> If both types of substitutions are available for the same protein, so 
>> much the better.
>> A good example is normal and sickle cell hemoglobin, but I would like 
>> to have somewhere between four and ten different protein examples. I 
>> need some that affect binding or enzymatic activity and are located 
>> in the binding or active site.
>> Thanks in advance for suggestions on this topic.
>> Frieda
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