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Synthetome is the total of all artificial gene/genetic products in a given system. The term was proposed by Chiliveru S et al.[1]

In the recent past, the system-wide genomics approach has considerably improved the translation of bioinformatics data generated into wet-lab experiments for predicting better drug targets. There has been a significant growth in understanding the immune response for those candidate (pathogenic and synthetases) genes linked to antigenicity.[2] This framework of protein–protein interaction networks constituting synthetases could be potential co-targets for many proteins.[3] Furthermore, their predicted role would initiate resistance for many drugs where such targets were earlier shown to form a class of resistome proteins and have been extensively identified in Mycobacterium.[4]


  1. Chiliveru et al. 2014
  2. Liang et al. 2011
  3. Chiliveru et al. 2014
  4. Padiadpu et al. 2010

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