[Molvis-list] pdb files of wild type/mutants

[Paul Pillot]

1j46 & 1j47 represent the hmg box portion of SRY protein. They only 
differ by 1 amino-acid, but the mutation causes a change in shape, 
making the protein unable to bend correctly the DNA in order to initiate 
the transcription.

Paul

Frieda Reichsman a écrit :

> Dear Colleagues,
>
> I am seeking pdb files to use as paired examples of the effects of a 
> single amino acid substitution on protein structure/function. Ideally 
> I would like to have some examples of substitutions that alter 
> function, and some that have little or no evident functional effect. 
> If both types of substitutions are available for the same protein, so 
> much the better.
>
> A good example is normal and sickle cell hemoglobin, but I would like 
> to have somewhere between four and ten different protein examples. I 
> need some that affect binding or enzymatic activity and are located in 
> the binding or active site.
>
> Thanks in advance for suggestions on this topic.
>
> Frieda
>