Basic Information
Gene ID 21416 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name Tcf7l2; Tcf4
Full Name Transcription factor 7-like 2
Organism Mus musculus [10090]

Cross Reference
UniProt Q924A0 UniGene Mm.139815
PDB NULL OMIM NULL
KEGG mmu:21416 UCSC uc008hyn.2

Protein Interactions
DIP DIP-40920N
IntAct Q924A0
MINT MINT-421706
STRING NULL

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSMUSP00000107284 Gene3D G3DSA:1.10.30.10 IPR009071 325 407 8.80e-29 High mobility group box domain
ENSMUSP00000107284 Gene3D G3DSA:4.10.900.10 IPR027397 1 60 2.00e-31 Catenin binding domain
ENSMUSP00000107284 PANTHER PTHR10373 IPR024940 1 598 0.00e-00 Transcription factor TCF/LEF
ENSMUSP00000107284 PANTHER PTHR10373:SF26 IPR028773 1 598 0.00e-00 Transcription factor 7-like 2
ENSMUSP00000107284 Pfam PF00505 IPR009071 327 394 1.10e-21 High mobility group box domain
ENSMUSP00000107284 Pfam PF08347 IPR013558 1 236 1.70e-92 CTNNB1 binding, N-teminal
ENSMUSP00000107284 ProSiteProfiles PS50118 IPR009071 327 395 0.00e-00 High mobility group box domain
ENSMUSP00000107284 SMART SM00398 IPR009071 326 396 3.90e-25 High mobility group box domain
ENSMUSP00000107284 SUPERFAMILY SSF47095 IPR009071 326 407 0.00e-00 High mobility group box domain

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSMUSP00000107284 PF08347 0 CTNNB1_binding N-terminal CTNNB1 binding
ENSMUSP00000107284 PF00505 5.4e-22 HMG_box HMG (high mobility group) box
ENSMUSP00000107284 PF09011 9.3e-08 HMG_box_2 HMG-box domain

Gene Ontology Annotation
Protein Entry Name Space Description
ENSMUSP00000107284 GO:0006351 biological_process transcription, DNA-templated
ENSMUSP00000107284 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSMUSP00000107284 GO:0006357 biological_process regulation of transcription from RNA polymerase II promoter
ENSMUSP00000107284 GO:0007275 biological_process multicellular organismal development
ENSMUSP00000107284 GO:0016055 biological_process Wnt signaling pathway
ENSMUSP00000107284 GO:0060070 biological_process canonical Wnt signaling pathway
ENSMUSP00000107284 GO:0005634 cellular_component nucleus
ENSMUSP00000107284 GO:0003677 molecular_function DNA binding
ENSMUSP00000107284 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSMUSP00000107284 GO:0008013 molecular_function beta-catenin binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
7425 Nasonia vitripennis 100120687 9597 Pan paniscus 100978424
9555 Papio anubis 101026705 7029 Acyrthosiphon pisum 100161896
6087 Hydra magnipapillata 100199257 10224 Saccoglossus kowalevskii 100303556
400682 Amphimedon queenslandica 100641322 34638 Metaseiulus occidentalis 100905988
39432 Saimiri boliviensis 101037011 13735 Pelodiscus sinensis 102459521
6239 Caenorhabditis elegans 171849 7070 Tribolium castaneum 641465
9606 Homo sapiens 6934 9615 Canis familiaris ENSCAFG00000011005
10141 Cavia porcellus ENSCPOG00000002152 51511 Ciona savignyi ENSCSAVG00000007833
10020 Dipodomys ordii ENSDORG00000011398 9365 Erinaceus europaeus ENSEEUG00000007595
7897 Latimeria chalumnae ENSLACG00000015707 9785 Loxodonta africana ENSLAFG00000018192
59463 Myotis lucifugus ENSMLUG00000008783 9669 Mustela putorius furo ENSMPUG00000002032
61853 Nomascus leucogenys ENSNLEG00000015863 9986 Oryctolagus cuniculus ENSOCUG00000008142
30611 Otolemur garnettii ENSOGAG00000014475 9813 Procavia capensis ENSPCAG00000012331
7757 Petromyzon marinus ENSPMAG00000004519 132908 Pteropus vampyrus ENSPVAG00000016688
10116 Rattus norvegicus ENSRNOG00000049232 9305 Sarcophilus harrisii ENSSHAG00000017344
9823 Sus scrofa ENSSSCG00000010638 43179 Ictidomys tridecemlineatus ENSSTOG00000006847
37347 Tupaia belangeri ENSTBEG00000002995 31033 Takifugu rubripes ENSTRUG00000012549
9478 Tarsius syrichta ENSTSYG00000012796 8364 Xenopus tropicalis ENSXETG00000018735
8083 Xiphophorus maculatus ENSXMAG00000014710 7668 Strongylocentrotus purpuratus 373203
7227 Drosophila melanogaster 43769 28377 Anolis carolinensis ENSACAG00000010433
9646 Ailuropoda melanoleuca ENSAMEG00000015382 9913 Bos taurus ENSBTAG00000021574
9358 Choloepus hoffmanni ENSCHOG00000005968 7719 Ciona intestinalis ENSCING00000002003
9483 Callithrix jacchus ENSCJAG00000018987 7955 Danio rerio ENSDARG00000004415
9361 Dasypus novemcinctus ENSDNOG00000012035 9796 Equus caballus ENSECAG00000024121
9371 Echinops telfairi ENSETEG00000018612 9685 Felis catus ENSFCAG00000018774
9315 Macropus eugenii ENSMEUG00000011191 9103 Meleagris gallopavo ENSMGAG00000005753
30608 Microcebus murinus ENSMICG00000007510 9544 Macaca mulatta ENSMMUG00000022799
13616 Monodelphis domestica ENSMODG00000010133 9258 Ornithorhynchus anatinus ENSOANG00000001579
8128 Oreochromis niloticus ENSONIG00000016240 9978 Ochotona princeps ENSOPRG00000005139
9601 Pongo abelii ENSPPYG00000002661 9598 Pan troglodytes ENSPTRG00000002949
42254 Sorex araneus ENSSARG00000012174 59729 Taeniopygia guttata ENSTGUG00000010805
9739 Tursiops truncatus ENSTTRG00000002360 30538 Vicugna pacos ENSVPAG00000008158