Basic Information
Gene ID 393202
Gene Name hif1ab; hif1a
Full Name Hypoxia inducible factor 1 alpha
Organism Danio rerio [7955]

Cross Reference
UniProt Q6EHI4 UniGene Dr.75612
PDB NULL OMIM NULL
KEGG dre:393202 UCSC NULL

Protein Interactions
DIP NULL
IntAct NULL
MINT NULL
STRING 7955.ENSDARP00000004329

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSDARP00000004329 Pfam PF08778 IPR014887 740 777 2.20e-23 HIF-1 alpha, transactivation domain, C-terminal
ENSDARP00000004329 Pfam PF11413 IPR021537 543 574 2.40e-16 Hypoxia-inducible factor, alpha subunit
ENSDARP00000004329 PRINTS PR01080 IPR001321 201 224 2.50e-06 Hypoxia-inducible factor-1 alpha
ENSDARP00000004329 PRINTS PR01080 IPR001321 427 445 2.50e-06 Hypoxia-inducible factor-1 alpha
ENSDARP00000004329 ProSiteProfiles PS50112 IPR000014 249 298 0.00e-00 PAS domain
ENSDARP00000004329 ProSiteProfiles PS50112 IPR000014 81 157 0.00e-00 PAS domain
ENSDARP00000004329 ProSiteProfiles PS50888 IPR011598 16 69 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain
ENSDARP00000004329 SMART SM00086 IPR001610 302 345 2.80e-10 PAC motif
ENSDARP00000004329 SMART SM00091 IPR000014 230 296 2.20e-09 PAS domain
ENSDARP00000004329 SMART SM00091 IPR000014 88 154 2.90e-10 PAS domain
ENSDARP00000004329 SMART SM00353 IPR011598 22 77 1.50e-11 Myc-type, basic helix-loop-helix (bHLH) domain
ENSDARP00000004329 SUPERFAMILY SSF47459 IPR011598 14 87 0.00e-00 Myc-type, basic helix-loop-helix (bHLH) domain
ENSDARP00000004329 SUPERFAMILY SSF55785 IPR000014 242 343 0.00e-00 PAS domain
ENSDARP00000004329 SUPERFAMILY SSF55785 IPR000014 97 197 0.00e-00 PAS domain
ENSDARP00000004329 TIGRFAM TIGR00229 IPR000014 101 167 1.60e-05 PAS domain
ENSDARP00000004329 TIGRFAM TIGR00229 IPR000014 249 331 3.30e-06 PAS domain

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSDARP00000004329 PF14598 4.7e-26 PAS_11 PAS domain
ENSDARP00000004329 PF08778 8.3e-24 HIF-1a_CTAD HIF-1 alpha C terminal transactivation domain
ENSDARP00000004329 PF08447 3e-22 PAS_3 PAS fold
ENSDARP00000004329 PF11413 9.7e-17 HIF-1 Hypoxia-inducible factor-1
ENSDARP00000004329 PF00989 3.7e-14 PAS PAS fold
ENSDARP00000004329 PF13426 2.6e-09 PAS_9 PAS domain
ENSDARP00000004329 PF08448 5.2e-06 PAS_4 PAS fold

Gene Ontology Annotation
Protein Entry Name Space Description
ENSDARP00000004329 GO:0001666 biological_process response to hypoxia
ENSDARP00000004329 GO:0006351 biological_process transcription, DNA-templated
ENSDARP00000004329 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSDARP00000004329 GO:0007165 biological_process signal transduction
ENSDARP00000004329 GO:0045893 biological_process positive regulation of transcription, DNA-templated
ENSDARP00000004329 GO:0045944 biological_process positive regulation of transcription from RNA polymerase II promoter
ENSDARP00000004329 GO:0071456 biological_process cellular response to hypoxia
ENSDARP00000004329 GO:0005634 cellular_component nucleus
ENSDARP00000004329 GO:0005737 cellular_component cytoplasm
ENSDARP00000004329 GO:0003677 molecular_function DNA binding
ENSDARP00000004329 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSDARP00000004329 GO:0004871 molecular_function signal transducer activity
ENSDARP00000004329 GO:0035035 molecular_function histone acetyltransferase binding
ENSDARP00000004329 GO:0046983 molecular_function protein dimerization activity

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9483 Callithrix jacchus 100411678 61853 Nomascus leucogenys 100582446
8128 Oreochromis niloticus 100703737 9597 Pan paniscus 100993223
9555 Papio anubis 100999094 39432 Saimiri boliviensis 101044689
9685 Felis catus 101083686 8083 Xiphophorus maculatus 102217674
7897 Latimeria chalumnae 102348279 7029 Acyrthosiphon pisum 100167974
10224 Saccoglossus kowalevskii 100329032 9669 Mustela putorius furo 101692645
13735 Pelodiscus sinensis 102457736 9615 Canis familiaris 480348
10090 Mus musculus 53417 9598 Pan troglodytes 746195
28377 Anolis carolinensis ENSACAG00000016205 9646 Ailuropoda melanoleuca ENSAMEG00000003105
9358 Choloepus hoffmanni ENSCHOG00000008208 10141 Cavia porcellus ENSCPOG00000005317
10020 Dipodomys ordii ENSDORG00000004304 69293 Gasterosteus aculeatus ENSGACG00000008525
9595 Gorilla gorilla ENSGGOG00000003957 59463 Myotis lucifugus ENSMLUG00000015244
9978 Ochotona princeps ENSOPRG00000007753 9601 Pongo abelii ENSPPYG00000005881
132908 Pteropus vampyrus ENSPVAG00000014497 10116 Rattus norvegicus ENSRNOG00000008292
9823 Sus scrofa ENSSSCG00000005096 99883 Tetraodon nigroviridis ENSTNIG00000017339
9478 Tarsius syrichta ENSTSYG00000001081 8364 Xenopus tropicalis ENSXETG00000014449
7668 Strongylocentrotus purpuratus 577801 7070 Tribolium castaneum 655772
9361 Dasypus novemcinctus ENSDNOG00000017069 9796 Equus caballus ENSECAG00000015597
9365 Erinaceus europaeus ENSEEUG00000005910 9031 Gallus gallus ENSGALG00000011870
8049 Gadus morhua ENSGMOG00000010900 9785 Loxodonta africana ENSLAFG00000013410
9103 Meleagris gallopavo ENSMGAG00000013552 30608 Microcebus murinus ENSMICG00000002224
13616 Monodelphis domestica ENSMODG00000008760 9258 Ornithorhynchus anatinus ENSOANG00000009092
9986 Oryctolagus cuniculus ENSOCUG00000017741 30611 Otolemur garnettii ENSOGAG00000016112
8090 Oryzias latipes ENSORLG00000002004 7757 Petromyzon marinus ENSPMAG00000000126
42254 Sorex araneus ENSSARG00000011198 9305 Sarcophilus harrisii ENSSHAG00000004128
43179 Ictidomys tridecemlineatus ENSSTOG00000004833 37347 Tupaia belangeri ENSTBEG00000011941
59729 Taeniopygia guttata ENSTGUG00000012978 31033 Takifugu rubripes ENSTRUG00000012093
9739 Tursiops truncatus ENSTTRG00000012558 30538 Vicugna pacos ENSVPAG00000002395