The current issue of Biochemistry and Molecular Biology Education (http://www.bambed.org/) is outstanding, and has more articles concerning structure than usual. The lead article is by Todd Weaver and Scott Cooper, "Exploring protein function and evolution using free online bioinformatics tools". In the next release of Protein Explorer, under Lesson Plans (linked to PE's FrontDoor), I will describe it as follows: This article describes a protein structure exercise within a bioinformatics course at Univ. Wisconsin-La Crosse, taught to about 40 students twice a year. This exercise is allocated 6-8 h in class (computer laboratory) plus homework. The software employed is Biology Workbench, Protein Explorer, and ConSurf. Students are assigned an amino acid sequence, and asked to make predictions about functional motifs, secondary structure (noting differences obtaine with different programs), hydrophobic and transmembrane regions. Students are then asked to assess the accuracy of the preditions, including secondary structure predictions assessed with an empirical 3D structure in Protein Explorer. Finally, students explore conservation in multiple sequence alignments between orthologs and paralogs, and examine conserved or hypervariable patches in the 3D structure. Seventeen proteins are listed that work well for this exercise. Online materials are provided. In the second article, Scott Cooper describes MERLOT, which has links to 1,300 electronic teaching resources in biology and chemistry. 20% of these have been peer-reviewed and rated in various categories. (http://www.merlot.org) In another article, Sayan Mukherjee et al. describe "A docking interaction study of the effect of critical mutations in ribonuclease A on protein-ligand binding", using AutoDock and PyMol (freely available for academic use). In yet another article, Scott E. Thompson and Duane Sears describe "Simplifying structure analysis projects with customizable chime- based templates". Duane is a pioneer in electronic structural biology and biochemistry education, and these are highly-developed teaching modules used at U. Cal. Santa Barbara. Their templates, tutorials, and course website are available at http://tutor.lscf.ucsb.edu/instdev/sears/biochemistry/presentations/ demos-downloads.htm -- http://tutor.lscf.ucsb.edu/instdev/sears/biochemistry/tutorials/ pdbtutorial/frontwindow.html -- http://tutor.lscf.ucsb.edu/instdev/sears/biochemistry/ Finally, Gale Rhodes, another pioneer in the field of structural biology education, provides a thoughtful analysis of his experiences, emphasizing the changing attitudes of peer-evaluation committees towards development of on-line educational resources, methods of weighting such activities vis a vis traditional publications, how he has documented his activities, and how his peers have responded. His popular website begins at http://www.usm.maine.edu/~rhodes Many other excellent articles, commentaries, websites of note, and a poem complete this outstanding issue. Judy and Don Voet, as editors in chief, are to be congratulated for their achievements in building the quality and quantity of BAMBEd's contents! -Eric /* - - - - - - - - - - - - - - - - - - - - - - - - - - - Eric Martz, Professor Emeritus, Dept Microbiology U Mass, Amherst -- http://www.umass.edu/molvis/martz Protein Explorer - 3D Visualization: http://proteinexplorer.org Workshops: http://www.umass.edu/molvis/workshop Biochem Structure Tutorials http://MolviZ.org World Index of Molecular Visualization Resources: http://molvisindex.org ConSurf - Find Conserved Patches in Proteins: http://consurf.tau.ac.il Atlas of Macromolecules: http://molvis.sdsc.edu/atlas/atlas.htm PDB Lite Macromolecule Finder: http://pdblite.org Molecular Visualization EMail List (molvis-list): http://bioinformatics.org/mailman/listinfo/molvis-list - - - - - - - - - - - - - - - - - - - - - - - - - - - */