A new, simple, browser-based tool for molecular visualization, FirstGlance in Jmol, is now available ( http://www.bioinformatics.org/firstglance ). FirstGlance is designed to be useful both to novices and to specialists. It works in all popular browsers and platforms, including Internet Explorer or Firefox on Windows, Safari on Mac OSX, and Mozilla Firefox on linux. A hyperlink to FirstGlance can show any PDB file in one click. It is free for all users, and its source code will be freely available for others to adapt. Key views are shown via one-click links from an always-visible control panel: secondary structure, amino and carboxy termini, general composition, hydrophobic vs. polar regions (or cores, using slab mode), charges, and multiple models when present (NMR). Convenience buttons show or hide ligands or water, toggle slab mode, zoom up/down, and change the background color. Help about each view or operation, including color keys, appears automatically, and is always in view. It was possible for me to create FirstGlance, which is a user interface to the Jmol java applet, only because of the outstanding efforts of the Jmol development team, especially Miguel Howard. I would also like to thank the bioinformatics.org team for providing a home for this project, especially Jeff Bizzaro; and Phil Bourne, Andy Sanderson, and the San Diego Supercomputer Center for providing a fast server. /* - - - - - - - - - - - - - - - - - - - - - - - - - - - Eric Martz, Professor Emeritus, Dept Microbiology U Mass, Amherst -- http://www.umass.edu/molvis/martz Protein Explorer - 3D Visualization: http://proteinexplorer.org Workshops: http://www.umass.edu/molvis/workshop Biochem Structure Tutorials http://MolviZ.org World Index of Molecular Visualization Resources: http://molvisindex.org ConSurf - Find Conserved Patches in Proteins: http://consurf.tau.ac.il Atlas of Macromolecules: http://molvis.sdsc.edu/atlas/atlas.htm PDB Lite Macromolecule Finder: http://pdblite.org Molecular Visualization EMail List (molvis-list): http://bioinformatics.org/mailman/listinfo/molvis-list - - - - - - - - - - - - - - - - - - - - - - - - - - - */