[Molvis-list] Major Histocompatibility Tutorial
emartz at microbio.umass.edu
Thu Sep 9 21:30:24 EDT 2010
A Jmol-based tutorial on the structure of Major Histocompatibility
Complex classes I & II proteins is now available at
http://MolviZ.Org. This is an enhanced version of the 1998
Chime-based tutorial (which in turn was an enhanced version of a 1995
RasMol Movie Script). The port was accomplished with the Jmol
Tutorial-Authoring Template (JTAT,
http://www.bioinformatics.org/jmol-tutorials/ ) which has been
upgraded to the current release of Jmol (version 12.0.12).
This tutorial is a ready-to-use lesson plan. It includes 21 challenge
questions. The questions are shown within the tutorial (in mint green
text), and are also available in a .doc file ready to print as
handouts for students. Suggestions for lesson structure are included
in the .doc file, which is linked in the Contents page of the tutorial.
New scenes in this tutorial include:
- MHC I colored by evolutionary conservation. (Chapter 4, View 6)
- Alignment of an 8 amino acid with a 9 amino acid peptide, as
bound in the cleft of the same MHC class I allele. (Chapter 6, View 3)
- Side by side comparison of two different viral epitopes in MHC
class I (with synchronized rotation; Chapter 6, View 4).
- Side by side comparison of epitopes in MHC class I vs. class II.
(Chapter 7, View 4)
Special thanks to Bob Hanson for his continued amazing development of
Jmol, and for fixing bugs and making changes that I requested.
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